| Eligibility |
Inclusion Criteria:
1. For the dose confirmation cohort, histologically confirmed diagnosis of NSCLC or
carcinomas of gastro-intestinal tract, including, but not limited to, colorectal
adenocarcinoma, pancreatic adenocarcinoma, and cholangiocarcinoma. For the Dose
Expansion cohorts, only NSCLC and colorectal adenocarcinoma histologies are eligible.
2. Presence of KRAS G12C mutation detected by assay performed in a CLIA-certified
environment.
3. Metastatic disease or locally advanced disease not amenable to local therapy.
4. ECOG performance status 0 or 1.
5. Presence of measurable disease per RECIST v1.1.
6. Any number of prior lines of therapy, including prior KRAS G12C inhibitor. For the
Dose Expansion cohorts, only treatment naïve NSCLC patients and colorectal
adenocarcinoma patients with disease progression on prior KRAS G12Ci are eligible.
NSCLC patients that completed curative intent treatment of their disease =6 months
prior to enrollment are eligible for frontline expansion cohort as long as they have
not been previously treated with a KRAS G12C inhibitor.
7. Age = 18 years.
8. Life expectancy of at least 3 months.
9. Most recent prior systemic therapy (e.g., chemotherapy, immunotherapy or,
investigational agent) and radiation therapy discontinued at least 2 weeks before
first dose date.
10. Recovery from the adverse effects of prior therapy at the time of enrollment to =
Grade 1 (excluding alopecia and parameters superseded by other eligibility criteria
[eg, laboratory parameters]).
11. Laboratory values within the screening period:
- Absolute neutrophil count = 1,000/mm3 (= 1.0 x 109/L)
- Platelet count = 100,000/mm3 (= 100 x 109/L)
- Hemoglobin = 9 g/dL
- Total bilirubin = 1.5 x Upper Limit of Normal (ULN) (if associated with liver
metastases or Gilbert's disease, = 3 x ULN)
- Aspartate transaminase (AST) and alanine transaminase (ALT) = 3.0 x ULN (if
associated with liver metastases, = 5 x ULN)
- Creatinine clearance =50 mL/min calculated using a validated prediction equation
(e.g., Cockcroft-Gault, MDRD, or 24-hour urine CrCl).
12. Women of child-bearing potential (WOCBP) or men whose partner is a WOCBP agrees to use
contraception while participating in this study, and for a period of 6 months
following termination of study treatment (see Reproductive Health below).
13. Completed informed consent process, including signing IRB/EC-approved informed consent
form.
14. Willing to comply with clinical trial instructions and requirements. Reproductive
Health
Patients who are biologically capable of having children and sexually active must agree to
use an acceptable method of contraception for the duration of the treatment period and for
at least 6 months after the last dose of study treatment. The Investigator will counsel the
patient on selection of contraception method and instruct the patient in its consistent and
correct use. Examples of acceptable forms of contraception include:
- Oral, inserted, injected or implanted hormonal methods of contraception, provided it
has been used for an adequate period of time to ensure effectiveness.
- Correctly placed copper containing intrauterine device (IUD).
- Male condom or female condom used WITH a spermicide.
- Male sterilization with confirmed absence of sperm in the post-vasectomy ejaculate.
- Bilateral tubal ligation or bilateral salpingectomy. Not engaging in sexual activity
for the total duration of the trial and the drug washout period is an acceptable
practice; however periodic abstinence, the rhythm method, and the withdrawal method
are not acceptable methods of birth control.
The Investigator will instruct the patient to call immediately if the selected birth
control method is discontinued or if pregnancy is known or suspected.
Note: Women are considered post-menopausal and/or not of child bearing potential if they
have had 12 months of natural (spontaneous) amenorrhea with an appropriate clinical profile
(e.g., age appropriate, history of vasomotor symptoms) or have had surgical
Exclusion criteria:
1. Radiation to the lung >30 Gy within 3 months prior to the first dose of study
treatment.
2. Active brain metastases. Patients are eligible if brain metastases are adequately
treated and patients are neurologically stable for at least 2 weeks prior to the first
dose of study treatment without the use of corticosteroids or are on a stable or
decreasing dose of = 10 mg daily prednisone (or equivalent).
3. Carcinomatous meningitis.
4. History of significant hemoptysis or hemorrhage within 4 weeks of the first dose date.
5. Active or prior documented autoimmune or inflammatory disease, as follows:
- Inflammatory bowel disease (e.g., Crohn's disease, ulcerative colitis).
- History of interstitial lung disease (ILD) or radiation pneumonitis requiring
steroid treatment, or any evidence of clinically active ILD or pneumonitis.
- Other medically important autoimmune disease within 2 years prior to the first
dose of study treatment. NOTE: Patients with Type 1 diabetes, vitiligo, Graves'
disease requiring only hormone replacement, hypothyroidism, or psoriasis not
requiring systemic treatment within the past 2 years are not excluded.
6. Immunocompromising conditions, as follows:
- Use of immunosuppressive medication within 28 days prior to the first dose of
study treatment, with the exceptions of corticosteroids.
- History of primary immunodeficiency.
- History of allogeneic transplant.
7. Receipt of a live vaccine within 30 days prior to first dose of study treatment.
8. Known severe hypersensitivity to study drugs and/or any of its excipients.
9. Known human immunodeficiency virus (HIV) infection or acute or chronic hepatitis B or
C infection. Patients treated for hepatitis C with no detectable viral load are
permitted.
10. Major surgery within 4 weeks prior to first dose of study treatment.
11. History of intestinal disease or major gastric surgery likely to alter absorption of
study treatment or inability to swallow oral medications.
12. Any of the following cardiac abnormalities:
- Unstable angina pectoris or myocardial infarction within the past 6 months.
- Symptomatic or uncontrolled atrial fibrillation within the past 6 months.
- Congestive heart failure =NYHA Class 3 within the past 6 months.
- Prolonged QTc interval >480 milliseconds, or immediate family or medical history
of congenital Long QT Syndrome.
13. History of stroke or transient ischemic attack within 6 months prior to first dose of
study treatment.
14. Ongoing need for a medication with any of the following characteristics that cannot be
switched to alternative treatment prior to study entry: known risk of QT prolongation
or Torsades de Pointes; substrate of CYP3A with narrow therapeutic index; strong
inducer of CYP3A and/or P-gp; strong inhibitor of BCRP; and proton pump inhibitors
(see Appendix 2).
15. Known or suspected presence of another malignancy that could be mistaken for the
malignancy under study during disease assessments.
16. Pregnancy. WOCBP must have a negative serum or urine pregnancy test documented within
the screening period prior start of study drug.
17. Breast-feeding or planning to breast feed during the study or within 6 months after
the last dose of study treatment.
18. Any serious illness, uncontrolled inter-current illness, psychiatric illness, active
or uncontrolled infection, or other medical history, including laboratory results,
which, in the Investigator's opinion, would be likely to interfere with the patient's
participation in the study, or with the interpretation of the results.
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