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A Prevention Trial of Canakinumab in Subjects at High Risk for Lung Cancer — CANAL  

Lung Cancer Clinical Trial

Official title:
A Phase III Prevention Trial of Canakinumab in Subjects at High Risk for Lung Cancer _ CANAL Study

Clinical Trial Summary

Randomized phase III, double-blind, placebo-controlled, multicenter clinical trial.

Clinical Trial Description

This is a multicentre, randomized, stratified, double-blind, placebo controlled, phase III study in subjects at high risk of lung cancer with hs CRP>3 mg/L undergoing annual screening low dose CT. The Sponsor anticipate to screen some 6.000 subjects, of whom about 700 will be recruited and evaluated in the randomized phase 3 trial. Eligible subjects will be randomized in a 3:2 ratio to receive either canakinumab s.c. at 200 mg or placebo every two months. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05725343
Study type Interventional
Source Mario Negri Institute for Pharmacological Research
Contact
Status Terminated
Phase Phase 3
Start date February 3, 2022
Completion date September 21, 2022
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