Xenon-enhanced Ventilation CT-guided Radiotherapy for Lung Cancer Treatment

Lung Cancer Clinical Trial

Official title:

Xenon-enhanced Ventilation CT-guided Radiotherapy for Lung Cancer Treatment: Functional Protection of the Lung and Prevention of Radiation Pneumonitis

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT05134558
• Other study ID #: 201912128RIN
• Status: Recruiting
• Phase: N/A
• Start date: February 4, 2020
• Est. completion date: December 31, 2024

Study information

• Verified date: September 2021
• Source: National Taiwan University Hospital
• Contact: Yu-Sen Huang, Md PhD
• Phone: +886-23123456
• Email: yusen0814[@]gmail.com
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The investigators aim to use xenon-enhanced ventilation computed tomography (CT) to design personalized functional lung avoidance radiotherapy for lung cancer patients who are scheduled to receive lung radiation therapy. The investigators' goal is to optimally protect the lung function of the patients and reduce the incidence of radiation pneumonitis.

Description:

There has been an increase in the application of radiation therapy in the treatment of lung tumors; however, the associated side effect, called radiation pneumonitis, can significantly reduce lung function and the quality of life of patients, eventually leading to fatal consequences. The investigators aim to use xenon-enhanced ventilation computed tomography (CT) to design personalized functional lung avoidance radiotherapy for lung cancer patients who are scheduled to receive lung radiation therapy. The investigators' goal is to optimally protect the lung function of the patients and reduce the incidence of radiation pneumonitis.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 60
• Est. completion date: December 31, 2024
• Est. primary completion date: December 31, 2024
• Accepts healthy volunteers: No
• Gender: All
• Age group: 20 Years to 80 Years

Eligibility

Inclusion Criteria:

• Patients aged 20-80 years, with lung cancer receiving thoracic radiotherapy in NTUH, from February 2020 to December 2024.

Exclusion Criteria:

• The age is less than 20 years old or older than 80 years old.

• Unstable clinical condition, unable to maintain apnea for 15 second, and history of prior adverse reaction to xenon.

• Renal insufficiency patients.

• Claustrophobia

• Those who are pregnant.

Related Conditions & MeSH terms

• Lung Cancer
• Lung Neoplasms
• Radiation Therapy Complication

Intervention

Radiation:
• Xenon-enhanced Ventilation CT-guided Radiotherapy
Xenon-enhanced Ventilation CT-guided Radiotherapy for functional protection of the lung

Locations

Country	Name	City	State
Taiwan	National Taiwan University Hospital	Taipei

Sponsors (1)

Lead Sponsor	Collaborator
National Taiwan University Hospital

Country where clinical trial is conducted

Taiwan, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Incidence of radiation pneumonia	Incidence of radiation pneumonia	Within 1 year of radiation therapy