PROSPECT - Profiling of Resistance Patterns & Oncogenic Signaling Pathways

Status Recruiting

Clinical Trial Summary

In this Project, we will use therapeutic target -focused (TTF) profiling, genome-wide mRNA profiling and assessments of tumor phosphopeptides and DNA that are shed into the blood stream to define how various molecular factors alone and in combination relate to resistance to therapy, to prognosis, and to metastatic patterns at relapse. We will examine how the presence of factors that drive cell growth, antagonize apoptosis, or confer resistance in other ways may counter the effect of systemic therapies and/or promote rapid tumor recurrence. In this way, we will identify new, previously unappreciated potential therapeutic targets while also identifying which targets are most likely to increase resistance to therapy and worsen prognosis.

Clinical Trial Description

Objectives: 1. To develop a therapeutic target -focused (TTF) profiling platform and to use it in vitro to identify potential therapeutic targets associated with therapeutic resistance and to develop novel approaches against these potential targets. 2. To use tumor tissue TTF profiling along with genome wide mRNA profiling, serum phosphopeptide profiling and plasma DNA profiling to identify and evaluate molecular targets and pathways that contribute to therapeutic sensitivity or resistance, prognosis, and recurrence patterns in patients with operable non-small cell lung carcinoma (NSCLC). ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05049837
Study type	Observational
Source	M.D. Anderson Cancer Center
Contact	Ignacio Wistuba, MD
Phone	713-563-9184
Email	iiwistuba@mdanderson.org
Status	Recruiting
Phase
Start date	April 25, 2007
Completion date	December 31, 2025

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PROSPECT - Profiling of Resistance Patterns & Oncogenic Signaling Pathways in Evaluation of Cancers of the Thorax and Therapeutic Target Identification

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms