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Monitoring Alectinib Treatment by Detection of ALK Translocations in Serial Blood Samples From Non-Small Cell Lung Cancer Patients — MonAlec  

Lung Cancer Clinical Trial

Official title:
Monitoring Alectinib Treatment by Detection of ALK Translocations in Serial Blood Samples From Non-Small Cell Lung Cancer Patients

Clinical Trial Summary

Circulating tumor DNA can be used to monitor the treatment effect and identify developing resistance mutations during ALK directed TKI treatment.

Clinical Trial Description

The purpose and objectives of the non-interventional study with primary data collection is - To determine if monitoring the amount of translocated DNA in the blood reflects alectinib treatment effect. - To assess the presence and type of resistance mutations using ctDNA at the time patients experience clinical progression on alectinib. - To investigate if the resistance mutations identified at clinical progression could have been identified in blood samples taken before clinically evident progression. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04708639
Study type Observational
Source Aarhus University Hospital
Contact
Status Enrolling by invitation
Phase
Start date June 19, 2019
Completion date June 30, 2025
View Details
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