Outcome
Type |
Measure |
Description |
Time frame |
Safety issue |
Other |
Dietary assessment |
Collected using 2 and 3-day food diaries. |
Baseline, preoperative, 4-week postoperative and 8-week postoperative |
|
Other |
Plasma phospholipid n-3 FA profile |
Plasma lipids will be extracted with organic solvents, phospholipids isolated on thin-layer chromatography, and FAs methylated for determination by gas chromatography-flame-ionization analysis. Used as an objective measure of adherence to fish oil. |
Baseline, preoperative, 4-week postoperative and 8-week postoperative |
|
Other |
Serum 25(OH)D |
Concentrations will be measured by the MUHC-Central Lab. Used as an objective measure of adherence to the supplement. |
Baseline, preoperative, 4-week postoperative and 8-week postoperative |
|
Other |
Inflammation |
Will be assessed with serum C-reactive protein (hs-CRP) by MUHC-Central Lab. |
Baseline, preoperative, 4-week postoperative and 8-week postoperative |
|
Other |
Serum albumin |
Will be analyzed as standard procedures by the MUHC-Central Lab. |
Baseline, preoperative, 4-week postoperative and 8-week postoperative |
|
Other |
Pre-albumin |
Will be analyzed as standard procedures by the MUHC-Central Lab. |
Baseline, preoperative, 4-week postoperative and 8-week postoperative |
|
Other |
Hemoglobin |
Will be analyzed as standard procedures by the MUHC-Central Lab. |
Baseline, preoperative, 4-week postoperative and 8-week postoperative |
|
Other |
Exercise tolerance - oxygen consumption |
Assessed using cardiopulmonary exercise testing and measuring oxygen consumption at anaerobic threshold and peak exercise |
Baseline, preoperative, 4-week postoperative and 8-week postoperative |
|
Other |
Exercise tolerance - workload |
Assessed by cardiopulmonary exercise testing at anaerobic threshold and peak exercise |
Baseline, preoperative, 4-week postoperative and 8-week postoperative |
|
Other |
Exercise tolerance - heart rate |
Assessed by cardiopulmonary exercise testing and measured at anaerobic threshold and peak exercise |
Baseline, preoperative, 4-week postoperative and 8-week postoperative |
|
Other |
Pulmonary function (FEV1) |
Spirometry standard methods to measure FEV1. |
Baseline and 4-week postoperative |
|
Other |
Pulmonary function (FVC) |
Spirometry standard methods to measure FVC. |
Baseline and 4-week postoperative |
|
Other |
Pulmonary function (FEV1/FVC) |
Spirometry standard methods to measure the FEV1/FVC ratio. |
Baseline and 4-week postoperative |
|
Other |
Pulmonary function (FEF 25-75%) |
Spirometry standard methods to measure FEF 25-75 percent. |
Baseline and 4-week postoperative |
|
Other |
Physical activity |
Community Healthy Activities Model Program for Seniors (CHAMPS) questionnaire, score 0 - x (no maximum score), higher mean more activity |
Baseline, preoperative, 4-week postoperative and 8-week postoperative |
|
Other |
Anxiety/depression |
Hospital Anxiety and Depression Scale (questionnaire). Scoring for each item ranges from zero to three. A subscale score >8 denotes anxiety or depression. |
Baseline, preoperative, 4-week postoperative and 8-week postoperative |
|
Other |
Nutritional status |
Patient-Generated Subjective Global Assessment (PG-SGA). In general, the higher total additive scores upon initial exam correlates with more severely malnourished cases (A = well nourished, B = moderately malnourished or suspected malnutrition and C = severely malnourished). |
Baseline, preoperative, 4-week postoperative and 8-week postoperative |
|
Primary |
Feasibility: Recruitment rate |
Recruitment rate (measured in percent, compared to expected rates) |
Over entire recruitment period (approximately 1 year) |
|
Primary |
Feasibility: Adherence to intervention |
Adherence to exercise and nutritional interventions (measured in percent, compared to expected rates) |
Over 12 weeks (4 weeks pre- and 8 weeks post-surgery) |
|
Primary |
Feasibility: completion of study outcome assessment |
Completion of study outcome assessments (measured in percent, compared to expected rates) |
Over 12 weeks (4 weeks pre- and 8 weeks post-surgery) |
|
Secondary |
Functional walking capacity |
Six-minute walking test: measured as the distance walked during 6 minutes, along a 20-m corridor, expressed in m) |
Baseline, preoperative, 4-week postoperative and 8-week postoperative |
|
Secondary |
Length of hospital stay |
Recorded from medical charts |
8-week postoperative |
|
Secondary |
Post-operative complications |
Recorded from medical charts and will be graded by severity following the Clavien-Dindo classification. |
8-week postoperative |
|
Secondary |
Health related quality of life |
Measured by the cumulative score of the 36-item Short Form Health Survey, score 0-100, higher score means better quality of life. |
Baseline, preoperative, 4-week postoperative and 8-week postoperative |
|
Secondary |
Quality of Life |
Measured by cumulative score of the Functional Assessment of Cancer Therapy - Lung questionnaires, score 0-136, higher means better quality of life. |
Baseline, preoperative, 4-week postoperative and 8-week postoperative |
|
Secondary |
Muscle strength - handgrip |
Handgrip strength using hand-held Jamar dynamometer, measured in kg. |
Baseline, preoperative, 4-week postoperative and 8-week postoperative |
|
Secondary |
Muscle strength - leg |
Isokinetic leg strength (knee extension peak torque) using Biodex, measured in N, on the dominant side. |
Baseline, preoperative, 4-week postoperative and 8-week postoperative |
|
Secondary |
Muscle volume |
Skeletal muscle volume will be measured in the dominant foreleg, using peripheral quantitative CT (pQCT, Stratec XCT2000). |
Baseline, preoperative, 4-week postoperative and 8-week postoperative |
|
Secondary |
Muscle radiodensity |
Skeletal muscle density will be measured in the dominant foreleg, using peripheral quantitative CT (pQCT, Stratec XCT2000). |
Baseline, preoperative, 4-week postoperative and 8-week postoperative |
|
Secondary |
Body composition |
Lean and fat mass will be measured by bioelectrical impedance (InBody 230V) |
Baseline, preoperative, 4-week postoperative and 8-week postoperative |
|