| Eligibility |
Inclusion Criteria:
1. Provision of informed consent prior to any study specific procedures
2. Adult male or female patients, aged from 30 to 75 years
3. Pathologic proven stage I lung adenocarcinoma with additional persistent GGNs in at
least one other lobe: GGN is defined as a ground glass-opacity with well-defined
margin, mean density above -500 HU and greater than 7.5 mm in its maximum diameter
4. The resected lung adenocarcinoma should have actionable EGFR mutation, which is
limited to L858R or exon 19 deletion.
5. WHO performance status 0-1 with no deterioration over the previous 2 weeks and a
minimum life expectancy of 12 weeks
6. Uneventful recovery from curative-intent lung cancer surgery
7. Female subjects should be using highly effective contraceptive measures, and must have
a negative pregnancy test and not be breast-feeding prior to start of dosing if of
childbearing potential or must have evidence of non-child-bearing potential by
fulfilling one of the following criteria at screening:
- Post-menopausal defined as aged more than 50 years and amenorrheic for at least
12 months following cessation of all exogenous hormonal treatments
- Women under 50 years old would be considered postmenopausal if they have been
amenorrheic for 12 months or more following cessation of exogenous hormonal
treatments and with LH and FSH levels in the post-menopausal range for the
institution
- Documentation of irreversible surgical sterilisation by hysterectomy, bilateral
oophorectomy or bilateral salpingectomy but not tubal ligation Further
information in Appendix E (Definition of Women of Childbearing Potential and
Acceptable Contraceptive Methods)
8. Male subjects should be willing to use barrier contraception (see Restrictions,
Section 3.8)
Exclusion Criteria:
1. Treatment with any neoadjuvant therapy (radiation, any cytotoxic chemotherapy,
investigational agents or other anticancer drugs after surgery) before randomization
2. Treatment with any adjuvant therapy (any cytotoxic chemotherapy, investigational
agents or other anticancer drugs after surgery) before randomization
3. Extensive surgery other than lobectomy or sublobar resection (i.e. bilobectomy, sleeve
lobectomy, pneumonectomy)
4. Past history of postoperative ALI/ARDS or pneumonia during recovery period
5. Currently receiving (or unable to stop use prior to receiving the first dose of study
treatment) medications or herbal supplements known to be strong inducers of CYP3A4 (at
least 3 week prior) (Appendix C). All patients must try to avoid concomitant use of
any medications, herbal supplements and/or ingestion of foodswith known inducer
effects on CYP3A4.
6. Any evidence of severe or uncontrolled systemic diseases, including uncontrolled
hypertension and active bleeding diatheses, which in the investigator's opinion makes
it undesirable for the patient to participate in the trial or which would jeopardise
compliance with the protocol, or active infection including hepatitis B, hepatitis and
human immunodeficiency virus (HIV). Screening for chronic conditions is not required.
7. Refractory nausea and vomiting, chronic gastrointestinal diseases, inability to
swallow the formulated product or previous significant bowel resection that would
preclude adequate absorption of osimertinib.
8. Any of the following cardiac criteria:
- Mean resting corrected QT interval (QTc) > 470 msec obtained from 3
electrocardiograms (ECGs), using the screening clinic ECG machine derived QTc
value. Whenever QTc, is mentioned in this document, this refers to correction e
made by Fridericia formula (QTcF),
- Any clinically important abnormalities in rhythm, conduction or morphology of
resting ECG e.g. complete left bundle branch block, third degree heart block and
second degree heart block.
- Patient with any factors that increase the risk of QTc prolongation or risk of
arrhythmic events such as heart failure, electrolyte abnormalities (including:
Serum/plasma potassium < LLN; Serum/plasma magnesium < LLN; Serum/plasma calcium
< LLN) , congenital long QT syndrome, family history of long QT syndrome or
unexplained sudden death under 40 years of age in first degree relatives or any
concomitant medication known to prolong the QT interval and cause Torsades de
Pointes
9. Past medical history of interstitial lung disease, drug-induced interstitial lung
disease, radiation pneumonitis which required steroid treatment, or any evidence of
clinically active interstitial lung disease.
10. Inadequate bone marrow reserve or organ function (as demonstrated by any of the
following laboratory values:
- Absolute neutrophil count <1.5 x 109/L;
- Platelet count <100 x 109/L;
- Haemoglobin <90 g/L;
- Alanine aminotransferase >2.5 times ULN if no demonstrable liver metastases or >5
times ULN in the presence of liver metastases;
- Aspartate aminotransferase >2.5 times ULN if no demonstrable liver metastases or
>5 times ULN in the presence of liver metastases;
- Total bilirubin >1.5 times ULN if no liver metastases or >3 times ULN in the
presence of documented Gilbert's Syndrome [unconjugated hyperbilirubinaemia] or
liver metastases;
- Serum creatinine >1.5 times ULN concurrent with creatinine clearance <50 mL/min
[measured or calculated by Cockcroft and Gault equation]-confirmation of
creatinine clearance is only required when creatinine is >1.5 times ULN.
11. Women who are breast-feeding.
12. Males and females of reproductive potential who are not using and effective method of
birth control and females who are pregnant or breastfeeding or have a positive (urine
or serum) pregnancy test prior to study entry.
13. Involvement in the planning and conduct of the study (applies to AstraZeneca staff or
staff at the study site).
14. Judgment by the investigator that the patient should not participate in the study if
the patient is unlikely to comply with study procedures, restrictions and
requirements.
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