Lung Cancer Clinical Trial
Official title:
An Exploratory Study on the Safety and Efficacy of Cryoablation Combined With Camrelizumab and Apatinib in the Treatment of Multiprimary Lung Cancer With Non-known Driving Genes
Objective: This study is to observe the safety and therapeutic effect of cryoablation
combined with pd-1 antibody immunotherapy and anti-angiogenesis therapy in multiple primary
lung cancer (MPLC) patients.
Methods: In this study, 20 patients with MPLC who conform to the admission criteria are
enrolled and began to receive treatment with Camrelizumab combined with Apatinib after
cryoablation.
Subjects who meet the admission criteria will be treated with Camrelizumab and Apatinib until
disease progression, intolerable toxicity, death, withdrawal of the patient or the
researchers determined that the drug must be discontinued.
The primary end point of this study is safety of cryoablation combined with carillizumab and
apatinib for MPLC. The secondary endpoints include objective response rate, disease control
rate, time to progression, progression free survival and overall survival. Exploratory
endpoint is to explore biomarkers in tumor tissue and blood that could potentially predict
the efficacy of Camrelizumab and Apatinib.
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