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NCT04007341 Clinical Trial

Effect of Dexmedetomidine on the Inflammatory Response After One-lung Ventilation

Lung Cancer Clinical Trial

Official title:
Effect of Dexmedetomidine on the Inflammatory Response in Patients Undergoing Lung Resection Surgery

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT04007341
Other study ID # KC16MISI0042
Secondary ID
Status Completed
Phase N/A
First received
Last updated
Start date July 29, 2018
Est. completion date January 18, 2019

Study information
Verified date June 2019
Source Seoul St. Mary's Hospital
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

The postoperative inflammatory response is significant in lung resection surgery because of major operation and one-lung ventilation. Dexmedetomidine has been shown to reduce pro-inflammatory cytokine levels and improve clinical outcomes. The aim of this study was to determine the effects of dexmedetomidine on inflammatory responses after lung resection surgery.

Recruitment information / eligibility
Status Completed
Enrollment 40
Est. completion date January 18, 2019
Est. primary completion date January 18, 2019
Accepts healthy volunteers No
Gender All
Age group 20 Years to 75 Years
Eligibility Inclusion Criteria:

- elective video-assisted thoracoscopic surgery (VATS) lobectomy

- 20 < age < 75

- American Society of Anesthesiologists (ASA) classification I~II

Exclusion Criteria:

- preoperative inflammation (CRP>10ng/#, WBC>10,000/mm3, body temperature >38#)

- steroid administration within 1 month

- hematologic / autoimmune disease

- congestive heart failure (NYHA class III~IV) or significant arrhythmia

- severe obstructive / restrictive pulmonary disease

- previous history of thoracic surgery

Study Design

Related Conditions & MeSH terms

Intervention

Drug:
• Dexmedetomidine
The study drug for each group was administered from the time immediately after induction of anesthesia until the end of the surgery.

Locations
Country Name City State
Korea, Republic of Seoul St.Mary's Hospital Seoul

Sponsors (1)
Lead Sponsor Collaborator
Seoul St. Mary's Hospital

Country where clinical trial is conducted

Korea, Republic of, 

Outcome
Type Measure Description Time frame Safety issue
Primary Interleukin (IL)-6 Blood samples were collected from the antecubital vein 24 hours after surgery
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