| Eligibility |
Inclusion Criteria:
1. Provision of signed and dated, written informed consent.
2. Age > 18 years.
3. Histologically or cytologically documented locally advanced or metastatic NSCLC not
amenable to curative surgery or radiotherapy. Patients that have received systemic
adjuvant therapy for non-metastatic disease in the past will need a new biopsy before
inclusion.
4. Documented EGFR mutation in exon 18-21, except insertions in exon 20, based on tissue
analysis.
5. ECOG status 0-2 and a minimum life expectancy of 12 weeks.
6. Patients with untreated, mild or moderately symptomatic and measurable brain
metastases are eligible, but will be allocated to cohort A (see excl. point 6).
Patients with pre-treated, stable and asymptomatic brain metastases will be allocated
to cohort B.
7. At least one lesion, not previously irradiated and not chosen for biopsy during the
study screening period, that can be accurately measured at baseline according to
RECIST 1.1.
8. Females should be using adequate contraceptive measures, should not be breast feeding
and must have a negative pregnancy test prior to start of dosing if of child-bearing
potential or must have evidence of non-child-bearing potential by fulfilling one of
the following criteria at screening:
- Post-menopausal defined as aged more than 50 years and amenorrhoeic for at least
12 months following cessation of all exogenous hormonal treatments
- Women under 50 years old would be considered postmenopausal if they have been
amenorrhoeic for 12 months or more following cessation of exogenous hormonal
treatments and with Luteinizing Hormone (LH) and Follicle-Stimulating Hormone
(FSH) levels in the post-menopausal range for the institution
- Documentation of irreversible surgical sterilisation by hysterectomy, bilateral
oophorectomy or bilateral salpingectomy but not tubal ligation.
9. Male subjects must be willing to use barrier contraception.
Exclusion Criteria:
1. Previous systemic treatment against metastatic NSCLC.
2. Major surgery within 4 weeks of inclusion
3. Radiotherapy treatment to more than 30% of the bone marrow or with a wide field of
radiation within 4 weeks of inclusion
4. Subjects currently receiving (or unable to stop using) potent inducers of CYP3A4.
Patients must stop using CYP3A4 inducers at least 3 weeks prior to treatment with
osimertinib (see appendix A).
5. Subjects with spinal cord compression unless they have completed definitive therapy,
are not on steroids and have had a stable neurological status for at least 2 weeks
after completion of definitive therapy and steroids.
6. Any evidence of severe or uncontrolled systemic diseases, including uncontrolled
hypertension and active bleeding diatheses, which in the investigator's opinion makes
it undesirable for the patient to participate in the trial or which would jeopardise
compliance with the protocol, or active infection including hepatitis B, hepatitis C
and human immunodeficiency virus (HIV). Screening for chronic conditions is not
required.
7. Previous malignancy (except non-melanoma skin cancers, and the following in situ
cancers: bladder, gastric, oesophageal, colon, endometrial, cervical, melanoma or
breast) unless a complete remission was achieved at least 2 years prior to study
entry.
8. Refractory nausea and vomiting, chronic gastrointestinal diseases, inability to
swallow the formulated product or previous significant bowel resection that would
preclude adequate absorption of osimertinib.
9. Exclude based on any of the following cardiac criteria:
- Mean resting corrected QT interval (QTc) > 470 msec obtained from 3
electrocardiograms (ECGs), using the screening clinic ECG machine derived QTc
value
- Any clinically important abnormalities in rhythm, conduction or morphology of
resting ECG e.g. complete left bundle branch block, third degree heart block and
second degree heart block
- Any factors that increase the risk of QTc prolongation or risk of arrhythmic
events such as heart failure, hypokalaemia, congenital long QT syndrome, family
history of long QT syndrome or unexplained sudden death under 40 years of age in
first degree relatives or any concomitant medication known to prolong the QT
interval
10. Past medical history of interstitial lung disease, drug-induced interstitial lung
disease, radiation pneumonitis which required steroid treatment, or any evidence of
clinically active interstitial lung disease.
11. Inadequate bone marrow reserve or organ function (as demonstrated by any of the
following laboratory values:
- Absolute neutrophil count < 1.5 x 109/L
- Platelet count < 100 x 109/L
- Haemoglobin < 90 g/L
- Alanine aminotransferase (ALT) > 2.5 times the upper limit of normal (ULN) if no
demonstrable liver metastases or > 5 times ULN in the presence of liver
metastases
- Aspartate aminotransferase (AST) > 2.5 times ULN if no demonstrable liver
metastases or > 5 times ULN in the presence of liver metastases
- Total bilirubin > 1.5 times ULN if no liver metastases or > 3 times ULN in the
presence of documented Gilbert's Syndrome (unconjugated hyperbilirubinaemia) or
liver metastases
- Serum creatinine >1.5 times ULN concurrent with creatinine clearance <50 mL/min
[measured or calculated by Cockcroft and Gault equation]-confirmation of
creatinine clearance is only required when creatinine is >1.5 times ULN
12. History of hypersensitivity of active or inactive excipients of osimertinib or drugs
with a similar chemical structure or class to osimertinib.
13. Treatment with an investigational drug within five half-lives of the compound or 3
months, whichever is greater.
14. Previous enrolment in the present study or previous treatment with osimertinib.
15. Any unresolved toxicities from prior therapy greater than CTCAE grade 1 at the time of
starting study treatment, with the exception of alopecia and grade 2, prior
platinum-therapy-related neuropathy.
16. Women who are pregnant or breast-feeding, or have a positive (urine or serum)
pregnancy test prior to study entry
17. Involvement in the planning and/or conduct of the study (investigator staff and/or
staff at the study site).
18. Judgment by the investigator that the subject should not participate in the study if
the subject is unlikely to comply with study procedures, restrictions and
requirements.
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