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Clinical Trial Details — Status: Not yet recruiting

Administrative data

NCT number NCT03234179
Other study ID # 201705110RIND
Secondary ID
Status Not yet recruiting
Phase N/A
First received July 26, 2017
Last updated July 30, 2017
Start date August 1, 2017
Est. completion date August 1, 2037

Study information

Verified date July 2017
Source National Taiwan University Hospital
Contact Tung-Ming Tsai, MD
Phone +886972792011
Email eldorado0607@gmail.com
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Lung cancer is a leading cause of cancer mortality among adults worldwide. The incidence rates of lung cancer among never smoking females in some parts of East Asia are among the highest in the world. The adenocarcinoma of lung being the most frequently identified histological type is more weakly associated with smoking, and often occurs in females and never-smokers. Although family history of lung cancer has been associated with histological subtypes, the inherited susceptibility factors that affect specific histology are unknown.

Genetic factors that determine individual predisposition to lung cancer have been identified via genome-wide association studies. These known common loci, however, explain only a small fraction of the familial risk of lung cancer. The hypothesis of this study is that there are genetic factors that confer inherited susceptibility among patients with primary non-small-cell lung cancer (NSCLC).


Description:

To delineate the genetic etiology underlying NSCLC, this study proposes to employ a family-based linkage analysis, together with rich data generated from NGS, to search for disease susceptibility locus for the patients with strong family history of primary NSCLC. By using family pedigrees, linkage analysis will be able to find co-segregation of alleles through multiple generations at a genetic susceptibility locus and a known genetic marker, and then the highly penetrate gene loci may be detected by our study. These gene loci will be a good genetic predictor of NSCLC which should be a great advantage in treatment, prevention and screening of NSCLC in the future.


Recruitment information / eligibility

Status Not yet recruiting
Enrollment 500
Est. completion date August 1, 2037
Est. primary completion date August 1, 2020
Accepts healthy volunteers No
Gender All
Age group 20 Years and older
Eligibility Inclusion Criteria:

1. The patient's family (within third-degree relatives) has at least one diagnosed of primary non-small cell lung cancer.

2. The patient was diagnosed of primary non-small cell lung cancer at the age < 45 years old.

Exclusion Criteria:

1. Patients without the diagnosis of primary non-small cell lung cancer.

2. Patients who are combined with other malignancy and ongoing chemotherapy / radiation therapy.

3. Patients combined with coagulopathy.

Study Design


Related Conditions & MeSH terms


Locations

Country Name City State
n/a

Sponsors (1)

Lead Sponsor Collaborator
National Taiwan University Hospital

Outcome

Type Measure Description Time frame Safety issue
Primary Genetic information of lung cancer patients Collect study subjects' blood sample and analysis with Genome-wide SNP genotyping One week after the study subjects sign the permit of informed consents
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