Lung Cancer Clinical Trial
Official title:
68Ga-NOTA-3P-TATE-RGD for Dual Somatostatin Receptor and Integrin αvβ3 PET/CT Imaging of Lung Cancer and Neuroendocrine Neoplams
This is an open-label positron emission tomography/computed tomography (PET/CT) study to investigate the diagnostic performance and evaluate the efficacy of 68Ga-NOTA-3PTATE-RGD in lung cancer patients and neuroendocrine neoplam patients. A single dose of 111-185 Mega-Becquerel (MBq) 68Ga-NOTA-3P-TATE-RGD will be injected intravenously. Visual and semiquantitative method will be used to assess the PET/CT images.
Status | Recruiting |
Enrollment | 100 |
Est. completion date | December 31, 2022 |
Est. primary completion date | December 1, 2020 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 80 Years |
Eligibility | Inclusion Criteria: - Neoplasm identified by X-ray, ultrasound or MRI as lung cancer or neuroendocrine tumors - To provide basic information and sign the written informed consent. Exclusion Criteria: - Consisted of conditions of mental illness; - Severe liver or kidney disease with serum creatinine > 3.0 mg/dl (270 µ?) or any hepatic enzyme level 5 times or more than normal upper limit; - Severe allergy or hypersensitivity to IV radiographic contrast - Claustrophobia to accept the PET/CT scanning - Pregnancy or breast feeding |
Country | Name | City | State |
---|---|---|---|
China | Peking Union Medical College Hospitall, Chinese Academy of Medical Science and Peking Union Medical College | Beijing | Beijing |
Lead Sponsor | Collaborator |
---|---|
Peking Union Medical College Hospital |
China,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Standardized uptake value of 68Ga-NOTA-3PTATE-RGD in lung cancer and Neuroendocrine Neoplasm | The semiquantitative analysis will be performed by the same person for all the cases, and the standardized uptake value (SUV) of the tracer in breast cancer will be measured. | 1 year |
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