Non-linear Multimodal Microendoscopy for Lung Cancer Pathology

Lung Cancer Clinical Trial

Official title:

Non-linear Multimodal Microendoscopy for Lung Cancer Pathology

Clinical Trial Details — Status: Withdrawn

Administrative data

• NCT number: NCT02699229
• Other study ID #: 14-7485
• Status: Withdrawn
• Start date: December 2020
• Est. completion date: January 2022

Study information

• Verified date: April 2021
• Source: University Health Network, Toronto
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

For this study the investigators are looking to do the following:

1. To characterize human lung lesions by nonlinear microscopy using ex vivo tissues.

2. To establish the first spectral/structural database for nonlinear optical microimaging of normal and abnormal lung tissue.

Description:

For this study the investigators are looking to do the following:

1. To characterize human lung lesions by nonlinear microscopy using ex vivo tissues. In particular, to investigate collagen content and ultrastructure with SHG (second harmonic generation) microscopy, to characterize cell and nuclear morphology and lipid vesicle content with THG (third harmonic generation) and CARS (coherent anti-Stokes Raman scattering) microscopy and to conduct spectroscopic and lifetime characterization of MPF (multiphoton fluorescence) signals in cancerous, benign, and normal tissues.

2. To establish the first spectral/structural database for nonlinear optical microimaging of normal and abnormal lung tissue, from which to generate diagnostic algorithms, both to optimize the operating parameters of planned nonlinear endoscopic imaging and to serve as the basis for nonlinear optical histopathology.

Recruitment information / eligibility

• Status: Withdrawn
• Enrollment: 0
• Est. completion date: January 2022
• Est. primary completion date: December 2021
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Age 18 years or older.

• Patients with confirmed or suspected lung cancer who require lobectomy as part of standard-of-care.

Exclusion Criteria:

• Patients deemed on clinical grounds not to be medically fit for a lobectomy

• Patients where there is a high clinical suspicion of lymphoma (to avoid mixing the data sets).

• Patients unable to give informed consent

Related Conditions & MeSH terms

• Lung Cancer
• Lung Neoplasms

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
University Health Network, Toronto

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Nonlinear optical microscopy for cancerous tissue detection in human lung lesions		Two years
Secondary	The first spectral/structural database for nonlinear optical micro-imaging of normal and abnormal lung tissue		Two Years