Non-linear Multimodal Microendoscopy for Lung Cancer Pathology

Lung Cancer Clinical Trial

Official title: Non-linear Multimodal Microendoscopy for Lung Cancer Pathology

Status Withdrawn

Clinical Trial Summary

For this study the investigators are looking to do the following:

1. To characterize human lung lesions by nonlinear microscopy using ex vivo tissues.

2. To establish the first spectral/structural database for nonlinear optical microimaging of normal and abnormal lung tissue.

Clinical Trial Description

For this study the investigators are looking to do the following:

1. To characterize human lung lesions by nonlinear microscopy using ex vivo tissues. In particular, to investigate collagen content and ultrastructure with SHG (second harmonic generation) microscopy, to characterize cell and nuclear morphology and lipid vesicle content with THG (third harmonic generation) and CARS (coherent anti-Stokes Raman scattering) microscopy and to conduct spectroscopic and lifetime characterization of MPF (multiphoton fluorescence) signals in cancerous, benign, and normal tissues.

2. To establish the first spectral/structural database for nonlinear optical microimaging of normal and abnormal lung tissue, from which to generate diagnostic algorithms, both to optimize the operating parameters of planned nonlinear endoscopic imaging and to serve as the basis for nonlinear optical histopathology. ;

Related Conditions & MeSH terms

• Lung Cancer
• Lung Neoplasms

• NCT number: NCT02699229
• Study type: Observational
• Source: University Health Network, Toronto
• Status: Withdrawn
• Start date: December 2020
• Completion date: January 2022