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NGS Genome Analysis in Personalisation of Lung Cancer Treatment — ALCAPONE  

Lung Cancer Clinical Trial

Official title:
Genome Analysis by Next Generation Sequencing in Personalisation of Lung Cancer Treatment

Clinical Trial Summary

The identification of driver mutations in the epidermal growth factor receptor (EGFR) as the primary oncogenic event in a subset of lung adenocarcinomas led to a model of targeted treatment and genetic profiling of the disease. EGFR tyrosine kinase inhibitors (TKIs) confer remission in some patients, but use of the EGFR-TKIs is limited to patients with adenocarcinomas who have known activating EGFR mutations. And resistance to TKI treatment has become an increasingly important cause of treatment failure. Therefore, identification of the molecular components involved could lead to the development of effective therapy. Today only a limited number of genetic alterations are studied.

Next Generation Sequencing (NGS) has the potential of becoming an important tool in clinical and therapeutic decision-making in oncology owing to its enhanced sensitivity in DND mutation detection.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02281214
Study type Interventional
Source Centre Georges Francois Leclerc
Contact
Status Completed
Phase N/A
Start date October 24, 2014
Completion date November 17, 2018
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