Lung Cancer Clinical Trial
Official title:
The Clinical Study of Personalized Therapy for Non-small Cell Lung Cancer Based on ERCC1/RRM1/TS Expression
Excision repair cross complementing 1 (ERCC1) ribonucleotide reductase M1 (RRM1) and
thymidylate synthase(TS) are molecular determinants that predict sensitivity or resistance to
platinum agents 、 gemcitabine and pemetrexed respectively.
Tailored therapy using these molecular determinants suggested patient benefit in a previously
reported phase 2 trial. Here, we designed a study for an individual patient analysis of
prospectively accrued patients who were treated with the "personalized therapy" approach
versus other standard approaches.
Patients who had nonsmall- cell lung cancer (NSCLC) performance status of 0/1 were accrued to
2 phase 2 clinical trials Trial A (carboplatin and chemotherapy individuation based on
sensitivity marker ), Trial B (carboplatin non-individuation or chemotherapy
non-individuation ).
Patients who were treated on Trials B were analyzed as the "standard therapy" group. Patients
accrued to Trial A were called the "personalized therapy" group. disease free survival (DFS)
was estimated using the Kaplan-Meier method.
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