Vitamin D Loading Dose in Advanced Lung Cancer

Status Completed

Clinical Trial Summary

Hypovitaminosis D is highly prevalent in people with lung cancer, and may have adverse clinical consequences. The long and variable pharmacokinetic half-life of vitamin D makes prompt vitamin D replacement problematic. This is an open, one-armed therapeutic intervention using a loading dose of vitamin D that will be predicted to increase plasma 25-hydroxyvitamin D concentrations of every patient well into the normal range (> 100 nmol/L) within 2 or 3 weeks and monitored after 2 and 3 weeks of loading and maintenance dose. Preliminary data will also be obtained to identify potentially clinical important outcome benefits for future investigation. The outcomes are

1. plasma 25OHD concentration

2. Vitamin D binding protein and other plasma concentrations

3. Mood and symptom

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT01631526
Study type	Interventional
Source	Jewish General Hospital
Contact
Status	Completed
Phase	N/A
Start date	June 2012
Completion date	February 2016

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