Lung Cancer Clinical Trial
Official title:
Phase 1 Study of Accelerated Hypofractionated Image-Guided Radiation Therapy (IGRT) in Patients With Stage II-IV Non-Small Cell Lung Cancer and Poor Performance Status
RATIONALE: Specialized radiation therapy that delivers a high dose of radiation directly to
the tumor may kill more tumor cells and cause less damage to normal tissue.
PURPOSE: This phase I trial is studying the side effects and best dose of specialized
radiation therapy in treating patients with stage II, stage III, stage IV, or recurrent
non-small cell lung cancer and poor performance status.
OBJECTIVES:
Primary
- To escalate the dose of accelerated hypofractionated image-guided conformal radiotherapy
to a potent tumoricidal dose without exceeding the maximum-tolerated dose in patients
with recurrent or stage II-IV non-small cell lung cancer and poor performance status.
Secondary
- To evaluate local regional tumor control and overall survival of patients treated with
this regimen.
OUTLINE: Patients undergo accelerated hypofractionated image-guided conformal radiotherapy
once daily, 5 days a week, for 3 weeks (15 fractions). Treatment continues in the absence of
disease progression or unacceptable toxicity.
After completion of study therapy, patients are followed up periodically for up to 5 years.
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