Lung Cancer Clinical Trial
Official title:
Phase II Study of Second-Line Bendamustine in Relapsed or Refractory Small Cell Lung Cancer (SCLC).
RATIONALE: Drugs used in chemotherapy, such as bendamustine, work in different ways to stop
the growth of tumor cells, either by killing the cells or by stopping them from dividing.
PURPOSE: This phase II trial is studying how well bendamustine works as second- or
third-line therapy in treating patients with relapsed or refractory small cell lung cancer.
OBJECTIVES:
Primary
- To determine the time to progression in patients with relapsed or refractory small cell
lung cancer treated with second- or third-line bendamustine.
Secondary
- To determine the toxicity of this drug in these patients.
- To determine the response rate, progression-free survival, and overall survival of
patients treated with this drug.
OUTLINE: This is a multicenter study.
Patients receive bendamustine IV over 1 hour on days 1 and 2. Treatment repeats every 21
days for up to 6 courses in the absence of disease progression or unacceptable toxicity.
After completion of study treatment, patients are followed up every 6-8 weeks.
;
Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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