Lung Cancer Clinical Trial
Official title:
The Cancer Genome Atlas (TCGA) Utilizing Z0030 NSCLC Patient Samples
RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may
help doctors learn more about changes that occur in DNA and identify biomarkers related to
cancer.
PURPOSE: This research study is looking at the cancer genome using tumor samples from
patients with stage I or stage II non-small cell lung cancer treated on clinical trial
ACOSOG-Z0030.
OBJECTIVES:
- To investigate the clinical relevance of conducting comprehensive molecular analyses on
clinically annotated high-quality tumor biospecimens from patients with stage I or II,
N0 or N1 (less than hilar) non-small cell lung cancer.
OUTLINE: This is a multicenter study.
Biological specimens are collected from participating clinical sites and analyzed by
transcription profiling of RNA and microRNA; detection of DNA copy number changes and
chromosomal rearrangements; epigenetic modifications analyses; and sequencing of genomic
segments, genes, and regulatory regions to assess sequence variation. Clinical information
associated with each specimen donor is also collected.
;
Observational Model: Cohort, Time Perspective: Prospective
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