Lung Cancer Clinical Trial
Official title:
Feasibility and Outcome of Cyberknife® Precision Hypofractionated Radiosurgery for the Curative Management of Non-Small Cell Lung Cancer
RATIONALE: Stereotactic radiosurgery can send x-rays directly to the tumor and cause less
damage to normal tissue.
PURPOSE: This phase I trial is studying the side effects and best dose of stereotactic
radiosurgery in treating patients with stage I or stage II non-small cell lung cancer.
OBJECTIVES:
- To establish the maximum tolerated dose of CyberKnife® hypofractionated stereotactic
radiosurgery in patients with medically inoperable, stage I or II non-small cell lung
cancer.
- To establish the relationship between positron emission tomography (PET) response and
local control and survival using fludeoxyglucose F 18 PET/CT imaging before treatment
and at 1, 3, 6, and 12 months after treatment.
OUTLINE: Patients undergo placement of 3 gold fiducial markers by CT-guidance or
bronchoscopy. Patients then undergo CyberKnife® hypofractionated stereotactic radiosurgery
over 45-120 minutes twice weekly for 2 weeks.
Patients undergo fludeoxyglucose F 18 PET/CT scan at baseline and at 1, 3, 6, and 12 months
after completion of treatment.
After completion of study treatment, patients are followed periodically for up to 4 years.
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