Low-Dose Chest Computed Tomography Screening for Lung Cancer in Survivors of Hodgkin's Disease

Lung Cancer Clinical Trial

Official title:

Low-Dose Chest Computed Tomography Screening for Lung Cancer in Survivors of Hodgkin's Disease

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00601146
• Other study ID #: 06-122
• Status: Completed
• Phase: N/A
• Start date: November 1, 2006
• Est. completion date: December 1, 2019

Study information

• Verified date: January 2020
• Source: Dana-Farber Cancer Institute
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

This research study is being done because patients with a history of chest radiation treatment for Hodgkin's disease have been shown to be at increased risk for developing lung cancer a number of years out from treatment. The risk appears to be further increased among patients with a smoking history. Currently, the practice is to recommend annual low-dose chest CT scans in survivors of Hodgkin's disease who have received prior chest radiation treatment and who have at least a moderate smoking history. In this study, the CT scans will be read and interpreted by the study radiologist, and the results recorded in a consistent manner.

Description:

- Participants will undergo a chest computed tomography (CT) scan once a year for a 3-year period.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 39
• Est. completion date: December 1, 2019
• Est. primary completion date: December 1, 2010
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• 5 years or longer from initial Hodgkin's disease diagnosis

• Current age 18 or older

• Received mediastinal irradiation and/or alkylating-agent based chemotherapy

• Smoking history of 10-pack years or more, or current smoker

• Pre-approval from the participant's insurance company for the CT study

Exclusion Criteria:

• Patients with a history of lung cancer

• Currently receiving treatment for another cancer diagnosis

• Known diagnosis of any metastatic cancer

• Pregnant women

Related Conditions & MeSH terms

• Hodgkin Disease
• Lung Cancer
• Lung Neoplasms

Intervention

Procedure:
• chest computed tomography scan
Once a year for three years

Locations

Country	Name	City	State
United States	Brigham and Women's Hospital	Boston	Massachusetts
United States	Dana-Farber Cancer Institute	Boston	Massachusetts

Sponsors (2)

Lead Sponsor	Collaborator
Dana-Farber Cancer Institute	Brigham and Women's Hospital

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	To Prospectively Collect Data on Chest CT Screening for Patients at Increase Lung-cancer Risk After Hodgkin's Disease.	In this study, patients will under annual low-dose chest CT screening. The total number of lung cancer detected through the screening will be recorded	3 years