Lung Cancer Clinical Trial
Official title:
Molecular Mechanism of Trophinin in Cancer Invasion and Metastasis
Our study established a model combine the in silico biology and empirical methods to identify clinically useful biomarker from information of microarray gene expression profiles in public domain. Through this method, we found trophinin as a novel prognostic marker for early stage lung cancer, which provide insight towards the process of cancer metastasis and the potential target for treatment.
This study was to combine the in silico biology and empirical methods to identify clinically
useful biomarker of lung cancer from microarray gene expression profiles in public database.
Using the expression profile of a known metastasis suppressor, CRMP-1, as a template to
search for and compare transcriptome expressions in publicly accessible microarray datasets,
trophinin (TRO) was identified as the best correlated gene. The expression pattern of
trophinin in a lung cancer cell lines of invasion model was investigated using quantitative
RT-PCR. The role of trophinin in cancer metastasis was investigated by measuring the change
of invasion activity in trophinin gene-transfected cell lines. The relationship of trophinin
and the clinicopathological characteristics of lung cancer were further examined by
immunohistochemical staining.
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Observational Model: Natural History, Time Perspective: Cross-Sectional
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