Lung Cancer Clinical Trial
Official title:
Phase II Study of Weekly Irinotecan and Carboplatin in Extensive-Stage Small-Cell Lung Cancer
RATIONALE: Drugs used in chemotherapy, such as irinotecan and carboplatin, work in different
ways to stop the growth of tumor cells, either by killing the cells or by stopping them from
dividing. Giving irinotecan together with carboplatin may kill more tumor cells.
PURPOSE: This phase II trial is studying how well giving irinotecan together with
carboplatin works in treating patients with newly diagnosed extensive-stage small cell lung
cancer.
OBJECTIVES:
Primary
- Determine the response rate in patients with newly diagnosed, previously untreated
extensive stage small cell lung cancer treated with irinotecan and carboplatin.
Secondary
- Determine the progression-free and overall survival of patients treated with this
regimen.
OUTLINE: This is a multicenter study.
Patients receive irinotecan IV and carboplatin IV on days 1 and 8. Treatment repeats every
21 days for 6 courses.
PROJECTED ACCRUAL: A total of 55 patients will be accrued for this study.
;
Masking: Open Label, Primary Purpose: Treatment
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