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NCT00024076 Clinical Trial

Radiofrequency Ablation in Treating Patients With Refractory or Advanced Lung Cancer

Lung Cancer Clinical Trial

Official title:
Radiofrequency Ablation of Pulmonary Malignancy

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT00024076
Other study ID # CDR0000068889
Secondary ID UCLA-9908024NCI-
Status Completed
Phase Phase 2
First received
Last updated
Start date May 2000

Study information
Verified date July 2012
Source Jonsson Comprehensive Cancer Center
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

RATIONALE: Radiofrequency ablation uses high-frequency electric current to kill tumor cells. CT-guided radiofrequency ablation may be effective treatment for lung cancer.

PURPOSE: Phase II trial to study the effectiveness of radiofrequency ablation in treating patients who have refractory or advanced lung cancer.

Description:

OBJECTIVES:

- Determine the safety and toxicity of radiofrequency ablation in patients with refractory or advanced pulmonary malignancies.

- Determine the efficacy of this treatment, in terms of local control, in these patients.

- Determine whether CT scan is a reasonable imaging assessment tool for treatment delivery and follow-up in these patients.

OUTLINE: Patients undergo percutaneous CT-guided radiofrequency ablation directly to the tumor over 2 hours.

Patients are followed at 1, 3, 6, and 12 months.

PROJECTED ACCRUAL: A total of 30 patients will be accrued for this study.

Recruitment information / eligibility
Status Completed
Enrollment 30
Est. completion date
Est. primary completion date December 2006
Accepts healthy volunteers No
Gender All
Age group N/A and older
Eligibility Inclusion Criteria:

- Diagnosis of a primary or secondary intrathoracic malignancy

- Any cell type or origin

- Involving the intrapulmonary, mediastinal, or pleural/chest wall

- Inoperable primary or metastatic cancer to the lung

- Refractory to or not amenable to conventional therapy (e.g., surgery, chemotherapy, or radiotherapy)

- Single or multiple lesions that are non-contiguous with vital structures or organs such as:

- Trachea

- Heart

- Aorta

- Great vessels

- Esophagus

- Less than 5 cm in largest dimension

- Accessible via percutaneous transthoracic route

- Hepatic:

- Coagulation profile normal

Study Design

Related Conditions & MeSH terms

Intervention

Procedure:
• radiofrequency ablation

Locations
Country Name City State
United States Jonsson Comprehensive Cancer Center, UCLA Los Angeles California

Sponsors (1)
Lead Sponsor Collaborator
Jonsson Comprehensive Cancer Center

Country where clinical trial is conducted

United States, 

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