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Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT00003313
Other study ID # RTOG-9801
Secondary ID CDR0000066260
Status Completed
Phase Phase 3
First received November 1, 1999
Last updated November 19, 2014
Start date September 1998
Est. completion date June 2010

Study information

Verified date November 2014
Source Radiation Therapy Oncology Group
Contact n/a
Is FDA regulated No
Health authority United States: Federal Government
Study type Interventional

Clinical Trial Summary

RATIONALE: Amifostine may be an effective treatment for the toxic side effects caused by radiation therapy and chemotherapy. It is not yet known whether chemotherapy and radiation therapy are more effective with or without amifostine for non-small cell lung cancer.

PURPOSE: Randomized phase III trial to determine the effectiveness of amifostine in treating patients who have stage II or stage III non-small cell lung cancer that cannot be surgically removed and who are undergoing chemotherapy and radiation therapy.


Description:

OBJECTIVES: I. Evaluate whether the addition of the radioprotector amifostine can reduce the incidence and severity of non-hematologic toxicity, specifically esophagitis and pneumonitis, during concurrent hyperfractionated radiotherapy and chemotherapy (with paclitaxel and carboplatin) in patients with stage II, IIIA, or IIIB non-small cell lung cancer. II. Evaluate the differences in quality of life and symptom distress, specifically dysphagia, between patients receiving amifostine and those not receiving amifostine. III. Evaluate the relationship of tobacco use and alcohol use during treatment to appraisals of quality of life and symptom distress, specifically esophagitis, in the two groups. IV. Evaluate the efficacy of induction therapy with paclitaxel and carboplatin followed by concurrent chemotherapy and hyperfractionated radiotherapy in these patients.

OUTLINE: This is an open-label treatment and randomized supportive care study. Patients are stratified according to disease stage (II vs IIIA vs IIIB), Karnofsky performance status (90-100% vs 70-80%), and age (70 and under vs over 70). Patients are randomized to one of two treatment arms. Arm I: Patients receive paclitaxel IV over 3 hours on days 1 and 22 and over 1 hour weekly for 6 weeks beginning on day 43. Patients receive carboplatin IV over 30 minutes immediately after each paclitaxel dose. Patients receive filgrastim (G-CSF) subcutaneously for 10-14 days after each of the first two paclitaxel and carboplatin doses. Radiotherapy begins on day 43 and is administered twice daily for 5 days per week for 6 weeks. Beginning on day 43, patients receive amifostine IV over 5-7 minutes 4 days a week for 6 weeks. Arm II: Patients receive treatment as in arm I without amifostine. Quality of life is assessed at baseline, before chemoradiation (after 2 courses of induction chemotherapy), the last week of chemoradiation (week 6), and at the 6-week follow-up visit. Patients are followed at 1 month, every 3 months for 1 year, every 6 months for 2 years, and then annually thereafter.

PROJECTED ACCRUAL: A total of 244 patients (122 per treatment arm) will be accrued for this study within 38 months.


Recruitment information / eligibility

Status Completed
Enrollment 243
Est. completion date June 2010
Est. primary completion date July 2002
Accepts healthy volunteers No
Gender Both
Age group 18 Years and older
Eligibility DISEASE CHARACTERISTICS: Histologically confirmed unresectable stage II, IIIA, or IIIB non-small cell lung cancer No distant metastases No prior complete (or gross subtotal) tumor resection No post-resection intrathoracic tumor recurrence Pleural effusion seen on a chest x-ray allowed only if appearing after thoracotomy or other invasive thoracic procedure (pleural effusion acceptable if seen only on CT scan, not on chest x-ray) Must be ineligible or refused participation in protocol RTOG-9309

PATIENT CHARACTERISTICS: Age: 18 and over Performance status: Karnofsky 70-100% Life expectancy: Not specified Hematopoietic: Absolute granulocyte count at least 2,000/mm3 Platelet count at least 100,000/mm3 Hemoglobin at least 8.0 g/dL Hepatic: Bilirubin no greater than 1.5 mg/dL* SGOT no greater than 1.5 times upper limit of normal* * Unless due to documented benign disease Renal: Creatinine no greater than 1.5 mg/dL Cardiovascular: No myocardial infarction within the past 6 months No symptomatic heart disease, including angina, congestive heart failure, or uncontrolled arrhythmias Other: No weight loss of greater than 5% in 3 months prior to diagnosis No other prior or concurrent invasive malignancy within the past 3 years except nonmelanomatous skin cancer Not pregnant or nursing Negative pregnancy test Fertile patients must use effective contraception

PRIOR CONCURRENT THERAPY: Biologic therapy: Not specified Chemotherapy: No prior chemotherapy Endocrine therapy: Not specified Radiotherapy: No prior thoracic or neck radiotherapy Surgery: See Disease Characteristics

Study Design

Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Supportive Care


Related Conditions & MeSH terms


Intervention

Biological:
filgrastim

Drug:
amifostine trihydrate

carboplatin

paclitaxel

Radiation:
radiation therapy


Locations

Country Name City State
Canada Tom Baker Cancer Center - Calgary Calgary Alberta
Canada Cross Cancer Institute Edmonton Alberta
Canada CHUS-Hopital Fleurimont Fleurimont Quebec
Canada Nova Scotia Cancer Centre Halifax Nova Scotia
Canada Cancer Care Ontario-Hamilton Regional Cancer Centre Hamilton Ontario
Canada Kingston Regional Cancer Centre Kingston Ontario
Canada Cancer Care Ontario-London Regional Cancer Centre London Ontario
Canada Centre Hospitalier de l'Universite de Montreal Montreal Quebec
Canada McGill University Montreal Quebec
Canada Ottawa Regional Cancer Centre - General Campus Ottawa Ontario
Canada Centre Hospitalier Universitaire de Quebec Quebec City Quebec
Canada Allan Blair Cancer Centre Regina Saskatchewan
Canada Saint John Regional Hospital Saint John New Brunswick
Canada Saskatoon Cancer Centre Saskatoon Saskatchewan
Canada Newfoundland Cancer Treatment and Research Foundation St. Johns Newfoundland and Labrador
Canada Northeastern Ontario Regional Cancer Centre, Sudbury Sudbury Ontario
Canada Northwestern Ontario Regional Cancer Centre, Thunder Bay Thunder Bay Ontario
Canada Princess Margaret Hospital Toronto Ontario
Canada Toronto Sunnybrook Regional Cancer Centre Toronto Ontario
Canada British Columbia Cancer Agency Vancouver British Columbia
United States Akron City Hospital Akron Ohio
United States Akron General Medical Center Akron Ohio
United States Cancer Center of Albany Medical Center Albany New York
United States Saint Joseph Medical Center Albuquerque New Mexico
United States Lehigh Valley Hospital Allentown Pennsylvania
United States Harrington Cancer Center Amarillo Texas
United States Providence Alaska Medical Center Anchorage Alaska
United States St. John's Medical Center Anderson Indiana
United States CCOP - Ann Arbor Regional Ann Arbor Michigan
United States University of Michigan Comprehensive Cancer Center Ann Arbor Michigan
United States Anne Arundel Oncology Center Annapolis Maryland
United States Northwest Community Hospital Arlington Heights Illinois
United States CCOP - Atlanta Regional Atlanta Georgia
United States Emory University Hospital - Atlanta Atlanta Georgia
United States Greater Baltimore Medical Center and Cancer Center Baltimore Maryland
United States Harbor Hospital Center Baltimore Maryland
United States Radiation Oncology Affiliates of Maryland, P.A. Baltimore Maryland
United States Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Baltimore Maryland
United States Sinai Hospital of Baltimore Baltimore Maryland
United States Mary Bird Perkins Cancer Center Baton Rouge Louisiana
United States Julie and Ben Rogers Cancer Institute Beaumont Texas
United States CCOP - Southwestern Vermont Regional Cancer Center Bennington Vermont
United States St. Luke's Hospital Regional Cancer Center Bethlehem Pennsylvania
United States CCOP - Montana Cancer Consortium Billings Montana
United States University of Alabama at Birmingham Comprehensive Cancer Center Birmingham Alabama
United States Bloomington Hospital Bloomington Indiana
United States Albert Einstein Comprehensive Cancer Center Bronx New York
United States New York Methodist Hospital Brooklyn New York
United States State University of New York Health Science Center at Brooklyn Brooklyn New York
United States Roswell Park Cancer Institute Buffalo New York
United States Vermont Cancer Center Burlington Vermont
United States Cooper Cancer Institute Camden New Jersey
United States Lineberger Comprehensive Cancer Center, UNC Chapel Hill North Carolina
United States Medical University of South Carolina Charleston South Carolina
United States Cancer Center at the University of Virginia Charlottesville Virginia
United States Martha Jefferson Hospital Charlottesville Virginia
United States Northwestern Memorial Hospital Chicago Illinois
United States University of Chicago Cancer Research Center Chicago Illinois
United States Barrett Cancer Center, The University Hospital Cincinnati Ohio
United States Christ Hospital Cincinnati Ohio
United States Lykes Center for Radiation Therapy Clearwater Florida
United States Cleveland Clinic Taussig Cancer Center Cleveland Ohio
United States Ireland Cancer Center Cleveland Ohio
United States University Hospitals of Cleveland Cleveland Ohio
United States Finger Lakes Radiation Oncology, P.C. Clifton Springs New York
United States Memorial Hospital Cancer Center Colorado Springs Colorado
United States Ellis Fischel Cancer Center - Columbia Columbia Missouri
United States Arthur G. James Cancer Hospital - Ohio State University Columbus Ohio
United States CCOP - Columbus Columbus Ohio
United States Medical Center/John B. Amos Community Cancer Center Columbus Georgia
United States Mount Diablo Medical Center Concord California
United States Northeast Medical Center Concord North Carolina
United States Geisinger Medical Center Danville Pennsylvania
United States Fitzgerald Mercy Hospital Darby Pennsylvania
United States Halifax Medical Center Daytona Beach Florida
United States CCOP - Central Illinois Decatur Illinois
United States University of Colorado Cancer Center Denver Colorado
United States Barbara Ann Karmanos Cancer Institute Detroit Michigan
United States Henry Ford Hospital Detroit Michigan
United States Delaware County Memorial Hospital Drexel Hill Pennsylvania
United States Cancer Center and Beckman Research Institute, City of Hope Duarte California
United States Wendt Regional Cancer Center of Finley Hospital Dubuque Iowa
United States Veterans Affairs Medical Center - East Orange East Orange New Jersey
United States Pocono Cancer Center East Stroudsburg Pennsylvania
United States John F. Kennedy Medical Center Edison New Jersey
United States Provena St. Joseph Hospital- Regional Cancer Care Center Elgin Illinois
United States Trinitas Hospital - Jersey Street Campus Elizabeth New Jersey
United States Meritcare Roger Maris Cancer Center Fargo North Dakota
United States Hurley Medical Center Flint Michigan
United States McLaren Regional Cancer Center Flint Michigan
United States Radiation Therapy Associates - Fort Myers Fort Myers Florida
United States California Cancer Center Fresno California
United States Saint Agnes Cancer Center Fresno California
United States University of Florida Health Science Center Gainesville Florida
United States University of Texas Medical Branch Galveston Texas
United States Glendale Memorial Hospital and Health Center Glendale California
United States Saint Mary's Hospital and Medical Center Grand Junction Colorado
United States St. Vincent Hospital Green Bay Wisconsin
United States Sutter Health West Cancer Research Group Greenbrae California
United States CCOP - Greenville Greenville South Carolina
United States East Carolina University School of Medicine Greenville North Carolina
United States RMH Regional Canter Center Harrisonburg Virginia
United States Ingalls Memorial Hospital Harvey Illinois
United States Penn State Geisinger Cancer Center Hershey Pennsylvania
United States Catawba Memorial Hospital Hickory North Carolina
United States MBCCOP - Hawaii Honolulu Hawaii
United States University of Texas - MD Anderson Cancer Center Houston Texas
United States Comprehensive Cancer Institute of Huntsville Huntsville Alabama
United States Huntsville Hospital System Huntsville Alabama
United States Cape Cod Hospital Hyannis Massachusetts
United States Clarion Health Partners Inc. Indianapolis Indiana
United States Community Hospitals of Indianapolis - Regional Cancer Center Indianapolis Indiana
United States Veterans Affairs Medical Center - Indianapolis (Roudebush) Indianapolis Indiana
United States Holden Comprehensive Cancer Center at The University of Iowa Iowa City Iowa
United States Jackson-Madison County General Hospital Jackson Tennessee
United States Veterans Affairs Medical Center - Boston (Jamaica Plain) Jamaica Plain Massachusetts
United States CCOP - Kalamazoo Kalamazoo Michigan
United States CCOP - Kansas City Kansas City Missouri
United States CCOP - Dayton Kettering Ohio
United States Gundersen Lutheran Medical Foundation La Crosse Wisconsin
United States University of California San Diego Cancer Center La Jolla California
United States Wilford Hall - 59th Medical Wing Lackland Air Force Base Texas
United States Romagosa Radiation Oncology Center Lafayette Louisiana
United States CCOP - Southern Nevada Cancer Research Foundation Las Vegas Nevada
United States Norris Cotton Cancer Center Lebanon New Hampshire
United States Albert B. Chandler Medical Center, University of Kentucky Lexington Kentucky
United States Central Baptist Hospital Lexington Kentucky
United States Veterans Affairs Medical Center - Lexington Lexington Kentucky
United States University of Arkansas for Medical Sciences Little Rock Arkansas
United States Loma Linda University Medical Center Loma Linda California
United States Veterans Affairs Medical Center - Long Beach Long Beach California
United States Monmouth Medical Center Long Branch New Jersey
United States Jonsson Comprehensive Cancer Center, UCLA Los Angeles California
United States USC/Norris Comprehensive Cancer Center and Hospital Los Angeles California
United States James Graham Brown Cancer Center Louisville Kentucky
United States Louisville Radiation Oncology Louisville Kentucky
United States Joe Arrington Cancer Research and Treatment Center Lubbock Texas
United States Southern Wisconsin Radiotherapy Center Madison Wisconsin
United States University of Wisconsin Comprehensive Cancer Center Madison Wisconsin
United States Merle M. Mahr Cancer Center Madisonville Kentucky
United States Elliot Regional Cancer Center Manchester New Hampshire
United States CCOP - North Shore University Hospital Manhasset New York
United States Marquette General Hospital Marquette Michigan
United States Marshfield Clinic Marshfield Wisconsin
United States Loyola University Medical Center Maywood Illinois
United States Health First Holmes Regional Medical Center Melbourne Florida
United States University of Tennessee, Memphis Cancer Center Memphis Tennessee
United States Community Memorial Hospital Menomonee Falls Wisconsin
United States Baptist Hospital of Miami Miami Florida
United States Sylvester Cancer Center, University of Miami Miami Florida
United States Veterans Affairs Medical Center - Miami Miami Florida
United States CCOP - Mount Sinai Medical Center Miami Beach Florida
United States MidMichigan Medical Center - Midland Midland Michigan
United States South Jersey Regional Cancer Center Millville New Jersey
United States Columbia Hospital Milwaukee Wisconsin
United States Medical College of Wisconsin Milwaukee Wisconsin
United States St. Joseph's Hospital Milwaukee Wisconsin
United States St. Luke's Medical Center Milwaukee Wisconsin
United States Veterans Affairs Medical Center - Milwaukee (Zablocki) Milwaukee Wisconsin
United States Trinity Cancer Care Center Minot North Dakota
United States MBCCOP - Gulf Coast Mobile Alabama
United States Alabama Oncology, LLC Montgomery Alabama
United States Fox Chase Cancer Center at Virtua Memorial Hospital Burlington County Mount Holly New Jersey
United States Ball Memorial Hospital Muncie Indiana
United States Vanderbilt-Ingram Cancer Center Nashville Tennessee
United States Cancer Institute of New Jersey New Brunswick New Jersey
United States CCOP - Ochsner New Orleans Louisiana
United States MBCCOP - LSU Health Sciences Center New Orleans Louisiana
United States Tulane University School of Medicine New Orleans Louisiana
United States Beth Israel Medical Center New York New York
United States Herbert Irving Comprehensive Cancer Center New York New York
United States Memorial Sloan-Kettering Cancer Center New York New York
United States Newark Beth Israel Medical Center Newark New Jersey
United States CCOP - Bay Area Tumor Institute Oakland California
United States Oklahoma University Medical Center Oklahoma City Oklahoma
United States St. Anthony Hospital Oklahoma City Oklahoma
United States Methodist Cancer Center - Omaha Omaha Nebraska
United States Nebraska Health System Omaha Nebraska
United States Florida Radiation Oncology Group Orange Park Florida
United States MD Anderson Cancer Center Orlando Orlando Florida
United States Bay Medical Center Panama City Florida
United States Gulf Coast Cancer Treatment Center Panama City Florida
United States Lutheran General Cancer Care Center Park Ridge Illinois
United States Bayshore Medical Center Pasadena Texas
United States Huntington Cancer Center Pasadena California
United States Methodist Medical Center of Illinois Peoria Illinois
United States Albert Einstein Cancer Center Philadelphia Pennsylvania
United States Fox Chase Cancer Center Philadelphia Pennsylvania
United States Hahnemann University Hospital Philadelphia Pennsylvania
United States Kimmel Cancer Center of Thomas Jefferson University - Philadelphia Philadelphia Pennsylvania
United States University of Pennsylvania Cancer Center Philadelphia Pennsylvania
United States Veterans Affairs Medical Center - Philadelphia Philadelphia Pennsylvania
United States Foundation for Cancer Research and Education Phoenix Arizona
United States Mercy Hospital of Pittsburgh Pittsburgh Pennsylvania
United States University of Pittsburgh Cancer Institute Pittsburgh Pennsylvania
United States Western Pennsylvania Hospital Pittsburgh Pennsylvania
United States Champlain Valley Physicians Hospital Medical Center Plattsburgh New York
United States Atlantic City Medical Center Pomona New Jersey
United States Cancer Care Center Pomona California
United States CCOP - Columbia River Program Portland Oregon
United States Maine Medical Center Portland Maine
United States Naval Medical Center, Portsmouth Portsmouth Virginia
United States Vassar Brothers Hospital Poughkeepsie New York
United States Roger Williams Medical Center/BUSM Providence Rhode Island
United States Southeastern Wisconsin Regional Cancer Center Racine Wisconsin
United States Rapid City Regional Hospital Rapid City South Dakota
United States Reading Hospital and Medical Center Reading Pennsylvania
United States Bon-Secours - St. Mary's Hospital Richmond Virginia
United States Massey Cancer Center Richmond Virginia
United States Valley Hospital Ridgewood New Jersey
United States Mayo Clinic Cancer Center Rochester Minnesota
United States University of Rochester Cancer Center Rochester New York
United States Regional Radiation Oncology Center at Rome Rome Georgia
United States William Beaumont Hospital Royal Oak Michigan
United States Green Mountain Oncology Group Rutland Vermont
United States Radiation Oncology Center - Sacramento Sacramento California
United States St. Mary's Medical Center Saginaw Michigan
United States Dixie Regional Medical Center Saint George Utah
United States Mallinckrodt Institute of Radiology Saint Louis Missouri
United States St. Louis University Health Sciences Center Saint Louis Missouri
United States CCOP - Metro-Minnesota Saint Louis Park Minnesota
United States Peninsula Regional Medical Center Salisbury Maryland
United States LDS Hospital Salt Lake City Utah
United States University of Utah Health Sciences Center Salt Lake City Utah
United States Radiation Medical Group, Inc. San Diego California
United States UCSF Cancer Center and Cancer Research Institute San Francisco California
United States O'Connor Hospital San Jose California
United States CCOP - Santa Rosa Memorial Hospital Santa Rosa California
United States Sarasota Radiation and Medical Oncology Center Sarasota Florida
United States Mercy Hospital Cancer Center - Scranton Scranton Pennsylvania
United States Virginia Mason Medical Center Seattle Washington
United States Grand View Hospital Sellersville Pennsylvania
United States Somerset Medical Center Somerville New Jersey
United States CCOP - Northern Indiana CR Consortium South Bend Indiana
United States CCOP - Upstate Carolina Spartanburg South Carolina
United States Deaconess Medical Center Spokane Washington
United States Cancer Research for the Ozarks Springfield Missouri
United States CCOP - Cancer Research for the Ozarks Springfield Missouri
United States CCOP - Syracuse Hematology-Oncology Associates of Central New York, P.C. Syracuse New York
United States Tallahassee Memorial Healthcare Tallahassee Florida
United States H. Lee Moffitt Cancer Center and Research Institute Tampa Florida
United States CCOP - Toledo Community Hospital Oncology Program Toledo Ohio
United States Community Medical Center Toms River New Jersey
United States David Grant Medical Center Travis Air Force Base California
United States St. Francis Medical Center Trenton New Jersey
United States William Beaumont Hospital - Troy Troy Michigan
United States Arizona Cancer Center Tucson Arizona
United States St. John Health System Tulsa Oklahoma
United States North Mississippi Medical Center/Cancer Center Tupelo Mississippi
United States Radiation Oncology Associates of West Alabama Tuscallosa Alabama
United States East Texas Medical Center - Cancer Institute Tyler Texas
United States New York Medical College Valhalla New York
United States Associated Radiologists, P.A. Warren New Jersey
United States Walter Reed Army Medical Center Washington District of Columbia
United States Waukesha Memorial Hospital Waukesha Wisconsin
United States Schiffler Cancer Center Wheeling West Virginia
United States Wilkes Barre General Hospital Wilkes-Barre Pennsylvania
United States CCOP - Christiana Care Health Services Wilmington Delaware
United States CCOP - Southeast Cancer Control Consortium Winston-Salem North Carolina
United States Comprehensive Cancer Center at Wake Forest University Winston-Salem North Carolina
United States CCOP - MainLine Health Wynnewood Pennsylvania
United States Yakima Valley Memorial Hospital Yakima Washington
United States Riverhill Radiation Oncology Yonkers New York
United States York Hospital York Pennsylvania

Sponsors (3)

Lead Sponsor Collaborator
Radiation Therapy Oncology Group National Cancer Institute (NCI), NRG Oncology

Countries where clinical trial is conducted

United States,  Canada, 

References & Publications (15)

Bruner DW. Outcomes research in cancer symptom management trials: the Radiation Therapy Oncology Group (RTOG) conceptual model. J Natl Cancer Inst Monogr. 2007;(37):12-5. — View Citation

Langer CJ, Swann S, Curran W, et al.: Reassessing prognostic factors in the era of combined modality therapy for locally advanced NSCLC: a retrospective analysis of RTOG 9410 and 9801. [Abstract] Int J Radiat Oncol Biol Phys 63 (2 Suppl 1): A-65, S39, 2005.

Machtay M, Bae K, Movsas B, Paulus R, Gore EM, Komaki R, Albain K, Sause WT, Curran WJ. Higher biologically effective dose of radiotherapy is associated with improved outcomes for locally advanced non-small cell lung carcinoma treated with chemoradiation: an analysis of the Radiation Therapy Oncology Group. Int J Radiat Oncol Biol Phys. 2012 Jan 1;82(1):425-34. doi: 10.1016/j.ijrobp.2010.09.004. Epub 2010 Oct 25. — View Citation

Machtay M, Swann S, Komaki R, et al.: What is the meaning of local-regional control after chemoradiation for locally advanced NSCLC? An RTOG analysis. [Abstract] Lung Cancer 50 (Suppl 2): A-O-041, S17, 2005.

Movsas B, Moughan J, Langer C, et al.: Randomized trial of amifostine in locally advanced non-small cell lung cancer (NSCLC) patients receiving chemotherapy and hyperfractionated radiation (HRT): long-term survival results of Radiation Therapy Oncology Gr

Movsas B, Moughan J, Sarna L, Langer C, Werner-Wasik M, Nicolaou N, Komaki R, Machtay M, Wasserman T, Bruner DW. Quality of life supersedes the classic prognosticators for long-term survival in locally advanced non-small-cell lung cancer: an analysis of R — View Citation

Movsas B, Scott C, Langer C, Werner-Wasik M, Nicolaou N, Komaki R, Machtay M, Smith C, Axelrod R, Sarna L, Wasserman T, Byhardt R. Randomized trial of amifostine in locally advanced non-small-cell lung cancer patients receiving chemotherapy and hyperfract — View Citation

Movsas B. Exploring the role of the radioprotector amifostine in locally advanced non-small cell lung cancer: Radiation Therapy Oncology Group trial 98-01. Semin Radiat Oncol. 2002 Jan;12(1 Suppl 1):40-5. — View Citation

Nicolaou N, Moughan J, Sarna L, et al.: Quality of life (QOL) supercedes the classic predictors of survival in locally advanced non-small cell lung cancer (NSCLC): an analysis of Radiation Therapy Oncology Group (RTOG) 9801. [Abstract] Int J Radiat Oncol

Sarna L, Swann S, Langer C, et al.: Is there a "disconnect" between physician and patient - reported outcomes (PROs): an analysis of RTOG 98-01. [Abstract] Int J Radiat Oncol Biol Phys 66 (3 Suppl 1): A-2595, S541, 2006.

Sarna L, Swann S, Langer C, Werner-Wasik M, Nicolaou N, Komaki R, Machtay M, Byhardt R, Wasserman T, Movsas B. Clinically meaningful differences in patient-reported outcomes with amifostine in combination with chemoradiation for locally advanced non-small — View Citation

Sause W, Scott C, Byhardt R, et al.: Combined chemotheray radiation therapy treatment in unresected non-small cell lung cancer: Radiation Therapy Oncology Group (RTOG) experience. Lung Cancer 29(suppl 2): 2000.

Siddiqui F, Bae K, Langer CJ, Coyne JC, Gamerman V, Komaki R, Choy H, Curran WJ, Watkins-Bruner D, Movsas B. The influence of gender, race, and marital status on survival in lung cancer patients: analysis of Radiation Therapy Oncology Group trials. J Thorac Oncol. 2010 May;5(5):631-9. — View Citation

Werner-Wasik M, Langer C, Movsas B. Amifostine in chemoradiation therapy for non-small cell lung cancer: review of experience and design of a phase II trial assessing subcutaneous and intravenous bolus administration. Semin Oncol. 2005 Apr;32(2 Suppl 3):S — View Citation

Werner-Wasik M, Scott C, Movsas B, et al.: Amifostine as mucosal protectant in patients with locally advanced non-small cell lung cancer (NSCLC) receiving intensive chemotherapy and thoracic radiotherapy (RT): results of the radiation therapy oncology gro

* Note: There are 15 references in allClick here to view all references

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