Lung Cancer Clinical Trial
Official title:
PHASE I STUDY OF TOPOTECAN AND THORACIC RADIATION
Phase I trial to study the effectiveness of topotecan and radiation therapy in treating patients who have solid tumors or lymphoma. Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage cancer cells. Combining chemotherapy with radiation therapy may kill more cancer cells.
Status | Completed |
Enrollment | 5 |
Est. completion date | September 2000 |
Est. primary completion date | April 2000 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 18 Years and older |
Eligibility |
DISEASE CHARACTERISTICS: - Microscopically confirmed solid tumor or lymphoma not potentially curable by conventional surgery or radiotherapy - Previously unirradiated disease scheduled to receive thoracic irradiation of up to 60 Gy, including pulmonary and esophageal tumors - No metastatic disease more effectively treated by systemic chemotherapy - No history of brain metastases PATIENT CHARACTERISTICS: - Age: 18 and over - Performance status: ECOG 0 or 1 - WBC at least 4,000 - ANC at least 1,500 - Platelets at least 100,000 - Bilirubin no greater than 1.5 mg/dL - Creatinine no greater than 1.5 mg/dL - Calcium no greater than 11.0 mg/dL - No pregnant or nursing women - Pregnancy test required, as appropriate - Effective contraception required of fertile patient PRIOR CONCURRENT THERAPY: - At least 4 weeks since chemotherapy (6 weeks since nitrosoureas and mitomycin) and recovered - At least 4 weeks since radiotherapy and recovered |
Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
Country | Name | City | State |
---|---|---|---|
United States | University of Wisconsin Comprehensive Cancer Center | Madison | Wisconsin |
Lead Sponsor | Collaborator |
---|---|
National Cancer Institute (NCI) |
United States,
Forouzannia A, Schiller J, Berlin J, Hutson P, Boothman D, Storer B, Wilding G, Mehta M. A phase I study of Topotecan, as a radiosensitizer, for thoracic malignancies. Lung Cancer. 2004 Apr;44(1):111-9. — View Citation
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