Lung Cancer Clinical Trial
Official title:
ALPHA INTERFERON AND CIS-RETINOIC ACID FOR THE TREATMENT OF SQUAMOUS CELL CARCINOMAS
RATIONALE: Chemoprevention therapy is the use of certain drugs to try to prevent the
development or recurrence of cancer. The use of isotretinoin may be an effective way to
prevent cancer or stop cancer from growing. Interferon alfa may interfere with the growth of
cancer cells. Combining isotretinoin and interferon may be an effective treatment for some
recurrent cancers.
PURPOSE: Phase II trial to study the effectiveness of interferon alfa plus isotretinoin in
treating patients with recurrent cancer.
OBJECTIVES: I. Determine the response rates to treatment with daily subcutaneous interferon
alpha plus oral isotretinoin in patients with advanced squamous cell carcinomas of the
following body sites: head and neck, cervix, skin, esophagus, lung, and penis. II. Determine
the toxicities and side effects of this treatment.
OUTLINE: Nonrandomized study. Single-agent Chemotherapy with Biological Response Modifier
Therapy. Isotretinoin, 13-CRA, NSC-329481; with Interferon alpha (Schering or Hoffmann-La
Roche), IFN-A, NSC-377523 or NSC-367982.
PROJECTED ACCRUAL: 14-50 patients per tumor category (and any other tumor location, if
available) will be enrolled. If none of the first 14 patients in any tumor category
responds, or if only 1/22, 2/30, 3/37, 4/44, or 5/50 respond, the treatment will be
considered ineffective for that tumor type.
;
Primary Purpose: Treatment
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