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Lung Cancer clinical trials

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NCT ID: NCT05833334 Recruiting - Lung Cancer Clinical Trials

Healthy Homes Study

HHS
Start date: June 1, 2023
Phase: N/A
Study type: Interventional

This study is about home air radon testing and has two phases. The goal of the first phase is to learn about renters' and homeowners' views and plans related to radon testing. The main question this phase aims to answer is: 1. Does taking part in a focus group with information about radon testing change people's plans to test for radon? Participants in the first study phase will: - Take a survey about their views on and plans for radon testing. - Take part in a focus group discussion about radon testing, during which they will receive information about radon testing. - Right after the focus group, take a survey about their plans for radon testing. The second phase is a pilot interventional study. The goal is to test interventions about radon testing with renters and homeowners who smoke and do not smoke. The main questions this phase aims to answer are: 1. Does the recruitment strategy result in enough participants enrolling within 3 months? 2. Will at least 80% of participants complete data collection activities? 3. Will more participants who view an online intervention developed by the researchers request free radon test kits, set them up in their homes, and complete radon testing, compared to participants who view a standard public health infographic? And will even more participants who receive reminder messages, in addition to the online intervention, request free radon test kits, set them up in their homes, and complete radon testing? Participants in this second phase will: - Take a survey about their views on and plans for radon testing. - View an intervention about radon testing. - Right after viewing the intervention, take a survey about their views on and plans for radon testing. - 2 months later, take a survey about what, if any, steps they've taken to test their homes for radon. - Provide the researchers permission to collect data from their State Radon Program on: a) whether they requested a free radon test kit and b) whether testing was completed. Some participants will receive reminder messages for 2 months after viewing the intervention. Researchers will compare an online intervention they developed about radon testing to: a) a standard public health infographic and b) their online intervention combined with reminder messages about radon testing. They will compare the interventions by proportion of participants who: a) request a free radon test kit from their State Radon Programs, b) set-up the radon test kit in their homes, and c) complete radon testing.

NCT ID: NCT05832008 Recruiting - Lung Cancer Clinical Trials

Increasing Adherence to Lung Cancer Screening

Start date: October 18, 2023
Phase: N/A
Study type: Interventional

Investigators are conducting a pragmatic randomized trial testing the effectiveness of patient and clinician nudge strategies on adherence to lung cancer screening (LCS) & diagnostic follow-up across eligible primary care clinicians & patients. Following the trial, a subsample of patients & clinicians will be invited to one-time semi-structured interview & survey to identify individual & system-level factors that may restrict or enhance the impact of strategies.

NCT ID: NCT05824273 Recruiting - Lung Cancer Clinical Trials

The INSPIRE-Lung Study

Start date: August 2, 2023
Phase: N/A
Study type: Interventional

LungTalk and leveraging Facebook-targeted Advertisement (FBTA) addresses the call to develop and test multi-level, cancer communication interventions using innovative methods and designs. The study's long term goal is to increase lung cancer screening uptake among appropriate, high-risk individuals nationwide.

NCT ID: NCT05804786 Recruiting - Lung Cancer Clinical Trials

Prospective Cohort of Diagnostic Bronchoscopy for Peripheral Lung Lesions

Start date: April 1, 2023
Phase:
Study type: Observational

The primary objective is To evaluate the usefulness and safety of advanced guided bronchoscopy for histological diagnosis of peripheral pulmonary lesions. The Secondary objective is to establish a strategy that can most effectively use endoscopes for early diagnosis of lung cancer in a real-world care environment by identifying patient/clinical/image/procedure-related characteristics that can optimize the practicality of emerging technologies.

NCT ID: NCT05803746 Recruiting - Colorectal Cancer Clinical Trials

PD-L2 Targeting Nanobody Radiotracer for PET Imaging of Solid Tumor

Start date: July 15, 2022
Phase: N/A
Study type: Interventional

The objective of this study is to construct a noninvasive approach using 68Ga- Mirc415 PET/CT to detect the PD-L2 expression of tumor lesion in patients with colorectal cancer, lung cancer and other solid tumor to identify patients benefiting from anti-PD-(L)1 treatment.

NCT ID: NCT05801406 Recruiting - Lung Cancer Clinical Trials

From Benchmark to Surgical Activity: the Role of Endobronchial Fiducial Markers for Ground Glass Lung Nodules Resection.

Vortex_US
Start date: March 24, 2023
Phase:
Study type: Observational [Patient Registry]

With the risen popularity of low-dose computed tomography (LDCT) for lung cancer screening, many patients present with peripheral pulmonary ground-glass nodules (GGNs) with a suspicious solid part. The appropriate diagnostic and management strategy for those lesions can be questionable. If malignancy is suspected, a surgical biopsy with the guidance of various localization methods available is recommended. Each localization method has its advantages and disadvantages. Therefore, it may not be possible to establish a gold standard for localizing indeterminate lung nodules since comparative clinical trials are lacking.

NCT ID: NCT05801133 Recruiting - Lung Cancer Clinical Trials

Pifenidone Prophylactic Therapy for Radiation Lung Injury in Patients Who Have Previously Received Immune Checkpoint Inhibitors

Start date: March 31, 2023
Phase: Phase 2
Study type: Interventional

Patients with advanced lung cancer who have previously received immunocheckpoint inhibitor therapy, undergone chest radiation therapy again have developed radiation induced lung injury. Pirfenidone has anti-inflammatory and anti fibrosis effects. This study is intended to evaluate the effectiveness of pirfenidone combined with radiotherapy in the prevention of radiation pneumonitis.

NCT ID: NCT05800587 Recruiting - Lung Cancer Clinical Trials

Dose Attenuated Chemotherapy in Compromised Patients With Lung Cancer

Start date: February 22, 2023
Phase: Phase 2
Study type: Interventional

This is an open-label, non-randomized, single-center, phase II study to evaluate the efficacy, toxicity and, tolerability of pre-specified dose attenuated chemotherapy regimens in lung cancer patients with comorbidities.

NCT ID: NCT05795959 Recruiting - Lung Cancer Clinical Trials

Ensuring Precision-Medicine Delivery for Veterans With Lung Cancer

Start date: April 20, 2023
Phase: N/A
Study type: Interventional

The goal of this study is to learn if using a lay VA volunteer, who will assist patients with education regarding precision medicine, can improve care quality and outcomes for Veteran patients with lung cancer.

NCT ID: NCT05794529 Recruiting - Lung Cancer Clinical Trials

Lung Tumor Protein Synthesis Rates in Lung Cancer Patients

LungMaas
Start date: March 2023
Phase:
Study type: Observational

The current study will recruit lung cancer patients to measure tissue protein synthesis rates of non-small cell lung carcinomas and healthy lung tissue. The protein synthesis rates of healthy lung tissue will be compared to lung tumor tissue to establish the remodeling characteristics of healthy versus cancerous lung tissues. We will also examine whether tissue protein synthesis rates of non-small cell lung carcinomas are associated with various tumor- (i.e., size, subclassification) and patient-derived (i.e., inflammation, lung function, smoking status, and smoking history) parameters.