Lung Cancer Clinical Trial
Official title:
Efficacy and Safety of Anlotinib Versus Docetaxel in Advanved Non-squamous Non-small-cell Lung Cancer Without EGFR Mutation Who Failed in First-line Platinum-based Doublet Chemotherapy: an Open, Muti-center, Randomized Controlled Trial
This study is conducted to explore the safety and efficacy of anlotinib, a tyrosine kinase inhibitors of Vascular Endothelial Growth Factor Receptor 2（VEGFR）、FGFR（Fibroblast Growth Factor Receptor）, Platelet-derived growth factor Receptor（PDGFR） and c-kit, vs docetaxel in advanced Non-squamous Non-small cell lung cancer harbouring wild-type epidermal growth factor receptor (EGFR) .
This is a multicentre randomised controlled clinical trial conducted in China to compare the
efficacy and and safety of Anlotinib vs Docetaxel in patients of EGFR mutation-negative
advanced nonsquamous non-small Cell Lung Cancer.
Eligible patients will be randomized to arm A and arm B:
Arm A: Patients on the anlotinib arm received 12mg anlotinib orally daily on day 1 to 14 of a
21-day cycle.
Arm B: Patients on the docetaxel arm received 75mg/m2 docetaxel as intravenous infusion on
day 1 of a 21-day cycle.
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