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Clinical Trial Summary

This study will look at the effects of amantadine on cognitive function in persons with Long COVID. It will also collect specimens to study possible causes of cognitive symptoms in Long COVID, and whether any lab tests can predict who will respond better to amantadine.


Clinical Trial Description

This study will enroll 60 subjects with Long COVID and cognitive symptoms such as problems with memory, concentration, speech and attention, and "brain fog." Subjects will be assigned randomly to two groups. One group will be treated with amantadine, the other group will receive placebo. The study will last 4 months. During that time, subjects will be assessed at regular intervals with symptom questionnaires, cognitive tests, and lab measurements. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT06055244
Study type Interventional
Source Ohio State University
Contact Andrew I Schamess, MD
Phone (614) 688-6470
Email andrew.schamess@osumc.edu
Status Recruiting
Phase Phase 1
Start date December 7, 2023
Completion date May 15, 2025

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