High Protein Diet in Patients With Long-chain Fatty Acid Oxidation Disorders

Long-chain 3-hydroxyacyl-CoA Dehydrogenase Deficiency Clinical Trial

Official title: Fatty Acid Oxidation and Body Weight Regulation in Long-chain Fatty Acid Oxidation Disorders.

Status Completed

Clinical Trial Summary

The study also determines if eating a diet higher in protein alters body composition, energy balance and metabolic control among patients with a long-chain fatty acid oxidation disorder.

Clinical Trial Description

At baseline, the amount of muscle and fat in the whole body and inside the liver and muscle will be measured. All subjects will complete a moderate treadmill exercise test and a test to determine how they use sugar (oral glucose tolerance test). The amount and type of energy burned by each subject will be measured. Subjects will be randomly assigned to follow either a high carbohydrate diet or a reduced carbohydrate, high protein diet for 4 months. At the end of 4 months, the tests will be repeated. ;

Related Conditions & MeSH terms

• Carnitine Palmitoyltransferase 2 Deficiency
• Long-chain 3-hydroxyacyl-CoA Dehydrogenase Deficiency
• Protein Deficiency
• Trifunctional Protein Deficiency
• Very Long-chain Acyl-CoA Dehydrogenase Deficiency

• NCT number: NCT01494051
• Study type: Interventional
• Source: Oregon Health and Science University
• Status: Completed
• Phase: Phase 1/Phase 2
• Start date: January 2006
• Completion date: January 2010