Logopenic Progressive Aphasia Clinical Trial
Official title:
[18F]-T807 PET/CT Imaging of Tau Pathology in Young Onset Focal Dementia
The central goal of this study is to determine and compare the similarities and differences in regional brain uptake of [18F]T807 in patients with typical Alzheimer's Disease (AD), Posterior Cortical Atrophy (PCA), and Logopenic Variant of Primary Progressive Aphasia (lvPPA). The investigators will correlate patterns of [18F]T807 binding with magnetic resonance imaging (MRI)-based regional volumetric and cortical thickness measures. If cerebral spinal fluid (CSF) samples are not available, patients may be asked to get an optional lumbar puncture (LP) for additional comparisons. The investigators will recruit 20 participants, 45-70 years old, with clinical evidence of young onset focal dementia.
n/a
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
NCT03887481 -
Targeting Language-specific and Executive-control Networks With Transcranial Direct Current Stimulation in Logopenic Variant PPA
|
N/A | |
Completed |
NCT01095744 -
Influence of Age on Amyloid Load in Alzheimer's Disease and in Atypical Focal Cortical Alzheimer's Disease
|
N/A | |
Recruiting |
NCT04193267 -
Can Magnetic Brain Stimulation Improve Language Function in Primary Progressive Aphasia
|
N/A | |
Active, not recruiting |
NCT04881617 -
Treatment for Speech and Language in Primary Progressive Aphasia
|
N/A | |
Recruiting |
NCT05386394 -
Transcranial Direct Current Stimulation in the Treatment of Primary Progressive Aphasia
|
Phase 2 | |
Recruiting |
NCT04122001 -
Effects of Electrical Stimulation on Verbal Learning in Typical and Atypical Alzheimer's Disease
|
N/A | |
Active, not recruiting |
NCT06181500 -
Home-Based Exercise in Primary Progressive Aphasia (HEPPA)
|
N/A | |
Recruiting |
NCT03153371 -
Early-onset Alzheimer's Disease Phenotypes: Neuropsychology and Neural Networks
|