Clinical Trials Logo

Clinical Trial Summary

The main purpose of this study is to assess the efficacy and safety of volrustomig compared to observation in participants with unresected locally advanced head and neck squamous cell carcinoma (LA-HNSCC) who have not progressed after receiving definitive concurrent chemoradiotherapy (cCRT).


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT06129864
Study type Interventional
Source AstraZeneca
Contact AstraZeneca Clinical Study Information Center
Phone 1-877-240-9479
Email information.center@astrazeneca.com
Status Recruiting
Phase Phase 3
Start date December 14, 2023
Completion date June 17, 2030

See also
  Status Clinical Trial Phase
Completed NCT03426657 - Radiotherapy With Double Checkpoint Blockade of Locally Advanced HNSCC Phase 2
Recruiting NCT05172245 - Testing the Addition of Ipatasertib to Usual Chemotherapy and Radiation for Head and Neck Cancer Phase 1
Completed NCT04949503 - A Real-world Study of the Efficacy and Safety of Nimotuzumab in Combination With Chemoradiotherapy for LASCCHN
Completed NCT04870840 - Image-guided Proton Therapy for the Treatment of Locally Advanced Unresectable Head and Neck Cancer Phase 1
Completed NCT04541355 - Sodium Thiosulfate in Preventing Ototoxicity for Squamous Cell Cancer Patients Undergoing Chemoradiation With Cisplatin Phase 2
Recruiting NCT03649048 - Low-Dose Weekly vs High-Dose Cisplatin N/A
Recruiting NCT05724602 - Radiotherapy Plus Xevinapant in Older Patients With Locally Advanced Head and Neck Squamous Cell Carcinoma Phase 2
Not yet recruiting NCT05773079 - Toripalimab Maintenance for Locally Advanced Head and Neck Squamous Cell Carcinoma Phase 2
Not yet recruiting NCT05861557 - Neoadjuvant Radiotherapy Combined With Toripalimab for Locally Advanced Head and Neck Squamous Cell Carcinoma Phase 2
Recruiting NCT05527782 - Induction Modified TPF Followed by Concurrent Chemoradiotherapy in Locally Advanced Squamous Cell Carcinoma of the Head and Neck Phase 2
Recruiting NCT05269381 - Personalized Neoantigen Peptide-Based Vaccine in Combination With Pembrolizumab for Treatment of Advanced Solid Tumors Phase 1/Phase 2
Recruiting NCT05376553 - Study of Cemiplimab - TP Induction Chemotherapy in Patients With Locally Advanced Squamous Cell Carcinoma of the Head and Neck Phase 1
Withdrawn NCT03875053 - Home Sleep Apnea Machine in Evaluating Obstructive Sleep Apnea in Patients With Stage III-IV Head and Neck Cancer N/A
Recruiting NCT04892173 - NBTXR3 With or Without Cetuximab in LA-HNSCC Phase 3
Withdrawn NCT05743270 - Study of RP3 in Combination With Nivolumab and Other Therapy in Patients With Locoregionally Advanced or Recurrent SCCHN Phase 2
Recruiting NCT06240689 - A Prospective Randomized Controlled Study of Immune Checkpoint Maintenance Therapy After Radiotherapy and Chemotherapy for Locally Advanced Head and Neck Tumors Based on Peripheral Blood CD8Tex Detection in Peripheral Blood Phase 2
Suspended NCT04454489 - Quad Shot Radiotherapy in Combination With Immune Checkpoint Inhibition Phase 2
Completed NCT01689194 - Efficacy Study of Genexol-PM and Cisplatin in Locally Advanced Head and Neck Cancer Phase 2
Recruiting NCT05245682 - Tolinapant and Radiation for Cisplatin-Ineligible, Previously Untreated, Locally Advanced Head and Neck Cancer Early Phase 1
Recruiting NCT04947241 - Toripalimab Combined With Gemcitabine and Cisplatin Treating Resectable Locally Advanced HNSCC Phase 1