Gastric Cancer Clinical Trial
Official title:
A Clinical Study of Adoptive Cellular Immunotherapy Using Pluripotent Killer T Cells Expressing Antibodies for Human Epidermal Growth Factor Receptor-2 (HER2) in Treating Patients With HER2-Positive Advanced Gastric Cancer With Liver Metastasis
Objectives:
The purpose of this study is to evaluate the safety and efficacy of PIK-HER2 cells in the
treatment of advanced Her2 high expressed gastric cancer with liver metastasis patients.
Methods:
This study designs a novel therapy using PIK-HER2 cells. 40 Her2 positive patients with
liver metastasis from gastric cancer will be enrolled. They are randomly divided into
dendritic cell-precision multiple antigen T cells (DC-PMAT) group and PIK-HER2 cells group.
Both DC-PMAT treatment and PIK-HER2 cells treatment will be performed every 3 weeks with a
total of three periods. The mail clinical indicators are Progression-Free-Survival and
Overall Survival.
A total of 40 patients may be enrolled over a period of 1-2 years. ;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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