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Compare Efficacy and Safety of Raltitrexed-based and 5fu-based Neoadjuvant Chemotherapy for Colorectal Liver Metastasis

Colorectal Cancer Clinical Trial

Official title:
The Second Affiliated Hospital of Zhejiang University

Clinical Trial Summary

This study is a multicenter ,randomization, open control study to evaluate the efficacy and safety of Raltitrexed-based chemotherapy and 5-fluorouracil-based chemotherapy in the peri-operative treatment of patients with Liver Metastasis From colorectal cancer (CRC).

Clinical Trial Description

The contrast analysis is separately done on Raltitrexed plus oxaliplatin and 5-fluorouracil plus oxaliplatin;Raltitrexed plus irinotecan and 5-fluorouracil plus irinotecan.To investigate the objective response rate,the R0 resection rate, the early tumor shrinkage （ETS）and depth of response(DPR) and the safety profile. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02453490
Study type Interventional
Source Zhejiang University
Contact
Status Terminated
Phase Phase 3
Start date October 11, 2015
Completion date September 11, 2019
View Details
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