| Eligibility |
Inclusion Criteria:
- Written informed consent must be obtained prior to any screening procedures.
- Cytohistological confirmation is required for diagnosis of HCC.
- Patients with advanced (unresectable and/or metastatic, stage C based on
Barcelona-Clinic Liver Cancer [BCLC] staging classification) hepatocellular carcinoma
which would not be suitable for treatment with loco-regional therapies or have
progressed following locoregional therapy such as surgical resection, percutaneous
hepatic arterial embolization, radiofrequency ablation, and percutaneous
interventional therapy.
- At least one tumor lesion meeting measurable disease criteria as determined by RECIST
v1.1. Lesions previously treated with local therapy, such as radiation therapy,
hepatic arterial embolization, radiofrequency ablation, and percutaneous
interventional therapy should not be selected unless progression is noted at baseline,
in which case, these lesions would be considered as non-target lesions.
- Current cirrhotic status of Child-Pugh class A-B, with no encephalopathy. Ascites
controlled by diuretics is permitted in this study.
- Availability of a representative tumor tissue specimen (archival tumor tissue is
allowed) at pre-screening.
- Eastern Cooperative Oncology Group Scale for Assessment of Patient Performance Status
= 2.
- Both men and women enrolled in this trial must use adequate barrier birth control
measures during the course of the trial and 4 weeks after the completion of trial.
- Adequate bone marrow, liver and renal function as assessed by central lab by means of
the following laboratory requirements from samples within 7 days prior to procedure:
- Hemoglobin > 100g/L
- Absolute neutrophil count >3.0 ×109/L
- Neutrophil count > 1.5 ×109/L
- Platelet count = 50.0 ×109/L
- Total bilirubin < 51 µmol/L
- Alanine transaminase (ALT) and aminotransferase (AST) < 5 x upper limit of normal
- Albumin > 28 g/L
- Prothrombin time (PT)-international normalized ratio (INR) < 2.3, or PT < 6
seconds above control
- Serum creatinine < 110 µmol/L
- Willing and able to comply with scheduled visits, treatment plan and laboratory tests.
Exclusion Criteria:
- Received any prior systemic chemotherapy or molecular-targeted therapy for HCC such as
sorafenib.
- Previous local therapy completed less than 4 weeks prior to the dosing and, if present
any related acute toxicity > grade 1.
- Any contraindications for hepatic arterial infusion procedure:
- Impaired clotting test (platelet count < 60000/mm3, prothrombin activity < 50%).
- Renal failure / insufficiency requiring hemo-or peritoneal dialysis.
- Known severe atheromatosis.
- Known uncontrolled blood hypertension (> 160/100 mm/Hg).
- Patients with any other malignancies within the last 3 years before study start.
- History of HCC tumor rupture.
- Patients with severe encephalopathy.
- Patients with known active bleeding (e.g. from GI ulcers, esophageal varices) within 2
months prior to baseline/screening visit or with history or evidence of inherited
bleeding diathesis or coagulopathy.
- Clinically significant (CTC grade 3 or 4) venous or arterial thrombotic disease within
past 6 months.
- History of cardiac disease:
- Congestive heart failure >New York Heart Association (NYHA) class 2 (refer to
Appendix 13.9).
- Active coronary artery disease (CAD) (myocardial infarction more than 6 months
prior to study entry is allowed).
- Cardiac arrhythmias (>Grade 2 NCI-CTCAE Version 4.0) which are poorly controlled
with anti-arrhythmic therapy or requiring pace maker.
- Uncontrolled blood hypertension (> 160/100 mm/Hg).
- Serious, non-healing wound, ulcer, or bone fracture.
- History of abdominal fistula, GI perforation, or intra-abdominal abscess within past 6
months prior to study treatment.
- Clinically significant third space fluid accumulation (i.e., ascites requiring tapping
despite use of diuretic or pleural effusion that either required tapping or is
associated with shortness of breath).
- Patients who have undergone major surgical procedure, open biopsy, or significant
traumatic injury within 4 weeks of the start of protocol treatment.
- History of a bone marrow or solid organ transplant.
- Use of biologic response modifiers, such as G-colony stimulating factor (CSF), within
3 weeks prior to start of study drug. (G-CSF and other hematopoietic growth factors
may be used in the management of acute toxicity such as febrile neutropenia when
clinically indicated or at the discretion of the investigator; however, they may not
be substituted for a required dose reduction). Subjects taking chronic erythropoietin
are permitted provided no dose adjustment is undertaken within 1 month prior to the
study or during the study.
- Any other condition that would, in the Investigator's judgment, contraindicate
patient's participation in the clinical study due to safety concerns or compliance
with clinical study procedures, e.g., infection/inflammation, intestinal obstruction,
unable or unwilling to swallow medication, social/ psychological issues, etc.
- Unable to undergo either contrast-enhanced magnetic resonance imaging (MRI) or
contrast-enhanced computed tomography (CT).
- Known history of human immunodeficiency virus (HIV) seropositivity. HIV testing is not
required as part of this study.
- Patients who have received any other investigational agents within a period of time
that is less than the cycle length used for that treatment or equal to 4 weeks
(whichever is shorter) prior to starting study drug and recovered from any side
effects to grade 1 or less.
- Pregnant or nursing (lactating) women, where pregnancy is defined as the state of a
female after conception and until the termination of gestation, confirmed by a
positive human chorionic gonadotropin (hCG) laboratory test.
- Women of child-bearing potential, defined as all women physiologically capable of
becoming pregnant, unless they are using highly effective methods of contraception
during dosing and for 7 days after permanently discontinuing HAIF and/or sorafenib
treatment. Highly effective contraception methods include:
- Total abstinence (when this is in line with the preferred and usual lifestyle of
the patient. Periodic abstinence (e.g., calendar, ovulation, symptothermal,
post-ovulation methods) and withdrawal are not acceptable methods of
contraception.
- Female sterilization (have had surgical bilateral oophorectomy with or without
hysterectomy) or tubal ligation at least six weeks before taking study treatment.
In case of oophorectomy alone, only when the reproductive status of the woman has
been confirmed by follow up hormone level assessment.
- Male sterilization (at least 6 months prior to screening). For female patients on
the study the vasectomized male partner should be the sole partner for that
patient.
- Combination of any two of the following (a+b or a+c, or b+c):
1. Use of oral, injected or implanted hormonal methods of contraception or
other forms of hormonal contraception that have comparable efficacy (failure
rate <1%), for example hormone vaginal ring or transdermal hormone
contraception.
2. Placement of an intrauterine device or intrauterine system
3. Barrier methods of contraception: Condom or Occlusive cap (diaphragm or
cervical/vault caps) with spermicidal foam/gel/film/cream/vaginal
suppository.
In case of use of oral contraception women should have been stable on the same pill for a
minimum of 3 months before taking study treatment.
Women are considered post-menopausal and not of child bearing potential if they have had 12
months of natural (spontaneous) amenorrhea with an appropriate clinical profile (e.g. age
appropriate, history of vasomotor symptoms) or have had surgical bilateral oophorectomy
(with or without hysterectomy) or tubal ligation at least six weeks ago. In the case of
oophorectomy alone, only when the reproductive status of the woman has been confirmed by
follow up hormone level assessment is she considered not of child bearing potential.
- Sexually active males unless they use a condom during intercourse while receiving
treatment and for 7 days after stopping study treatment and should not father a child
in this period. A condom is required to be used also by vasectomized men in order to
prevent delivery of the drug via seminal fluid.
- Subjects unable to suffer the discomfort of the HAI procedure (e.g. pain,
claustrophobia, noise).
- Any contraindication for sorafenib, oxaliplatin, leucovorin, or fluorouracil
administration.
- Any agents which could affect the absorption or pharmacokinetics of the study drugs.
- Known or suspected allergy to the investigational agents or any agent given in
association with this study.
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