Quality of Life Clinical Trial
Official title:
Short Versus Long IVF-treatment. A Prospective, Consecutive and Randomized Comparative Study
Purpose: Comparing a GnRH agonist and an antagonist protocol for IVF/ICSI with regard to
1. frequency of ovarian hyperstimulation syndrome (OHSS) (1. outcome measure)
2. quality of life (2. outcome measure)
3. live birth rate (2. outcome measure)
4. gene expression profiles of granulosa and cumulus cells, and concentrations of
estradiol and vascular endothelial growth factor in follicular fluid(not only compared
between GnRH agonist and antagonist protocol, but also between patients with OHSS and
no OHSS and patients becoming pregnant and not becoming pregnant (2. outcome measure),
and
5. number of oocytes removed per treatment, number of embryo transfers per treatment and
number of spontaneous abortions per treatment (these three parameters are tertiary
outcome measures).
In addition to the above mentioned efficacy outcome measures the safety outcome measure
"frequency of known side-effects" will be compared between the two protocols.
Patients: 1100 patients are randomized prospectively to either treatment. Stratification:
=<36 y/>36 y, IVF/ICSI, and treatment centre.
Methods: OHSS is quantified by consecutive measurements of weight, abdominal diameter,
ultrasound measurements of ascites and ovarian volume, paraclinical parameters, and by a
systematic patient questionnaire. Furthermore it is registered if the patients have been
hospitalized and/or have had ascites drainage performed due to OHSS. Data from the first 100
patients are used together with Golans OHSS-classification, to make a more precise
definition of OHSS. This definition is applied prospectively on data from the remaining
patients.
Quality of life is gauged by a questionnaire. Child birth rate is ascertained by a pregnancy
response questionnaire and by obtaining data from the Danish National Birth Registry.
Statistics: The study is designed to be able to show a 50% reduction of OHSS comparing short
to long protocol.
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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