Latent Tuberculosis Clinical Trial
Official title:
Latent Tuberculosis Infection in Korean Health Care Workers Using Interferon Gamma Releasing Assay
The investigators aim to study the prevalence of latent tuberculosis infection (LTBI) using whole-blood interferon-r release assays, and determine the risk factors of LTBI in Korean health care workers.
Status | Recruiting |
Enrollment | 240 |
Est. completion date | December 2017 |
Est. primary completion date | December 2017 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Both |
Age group | 20 Years to 65 Years |
Eligibility |
Inclusion Criteria: - Health care workers in University affiliated hospital - Adult aged 20-65 Exclusion Criteria: - Active tuberculosis - Subjects diagnosed with HIV infection, malignancy - Subjects having immunosuppressive drug therapy |
Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Screening
Country | Name | City | State |
---|---|---|---|
Korea, Republic of | Hanyang University Hospital | Seoul |
Lead Sponsor | Collaborator |
---|---|
Hanyang University |
Korea, Republic of,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Percentage of latent tuberculosis infection developed in Korean health care workers | The participants performed QuaniFERON-TB Gold In-Tube test (QFT-IT test) and blood sampling at enrollment. So, the length of time which from the start of the first test of very first participants to the end of test of very last participant is 3 months. The percentage of participants with LTBI in health care workers was evaluated. | Three months | No |
Secondary | Annual incidence of latent tuberculosis infection in Korean health care workers | QFT-IT test was performed at enrollment and repeated at point of one year after enrollment. So, the length of time which from the start of the first test of very first participants to the end of the second test of very last participant is 12 to 15 months. The percentage of participants with positive conversion in follow-up QFT-IT test (second test) was evaluated in participants who had negative results in the first QFT-IT test. Annual infection of LTBI was evaluated with the conversion of QFT-IT test through annual check up of QFT-IT test. | 1 year after first QFT-IT test (12-15 months) | No |
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