Latent Tuberculosis Clinical Trial
Official title:
Ultralow Dose Computed Tomography in Close Contacts at High Risk for Developing Multidrug- or Extensively Drug-resistant Tuberculosis: A Pilot Study
To evaluate CT abnormalities in the lung parenchyma in close contacts at high risk for developing multidrug- or extensively drug-resistant Tb by using a follow-up ultralow dose CT scan.
Multidrug- or extensively resistant tuberculosis tuberculosis is a major public health
threat worldwide and the global burden of drug-resistant tuberculosis is increasing.
Drug-resistant tuberculosis is associated with long period and high costs for treatment,
high rates of default, treatment failure and death.
Drug-resistant tuberculosis should be diagnosed rapidly so as to reduce potential
transmission. In the United States, at least one-fifths cases of multidrug-resistant
tuberculosis can be linked to transmission. Close contacts to drug-resistant tuberculosis
are at high risk for being transmitted and developing drug-resistant tuberculosis. There are
two options suggested for close contacts to drug-resistant tuberculosis: preventive therapy
and close observation. But both strategies are lack of sufficient evidence.
Ultralow chest CT scan may be an alternative for early identification and risk
stratification of developing active tuberculosis in close contacts to drug-resistant
tuberculosis with minimal radiation exposure similar to that of chest x-ray.
;
Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic
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