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Clinical Trial Summary

To investigate whether fish oil supplementation, compared to placebo (olive oil), could have better effects on depression course and cognitive function in older people with major depression.


Clinical Trial Description

Patients with late-life depression were reported cognitive impairment, especially in information-processing speed, working memory, attention and episodic memory, even after depressive symptoms subside and some of them further progress to dementia in two to four years. Several epidemiological studies, fatty acid comparison studies, animal studies, and clinical trials found that omega-3 polyunsaturated fatty acids (PUFAs) were significantly associated with the major depression, cognitive decline in general population and Alzheimer's disease. Until now, there is no study investigating the effects of n-3 PUFAs on depressive symptoms and cognition in patients with late-life depression. Thus, the aims of this study were to investigate whether fish oil supplementation, compared to placebo (olive oil), could have better effects on depression course and cognitive function in older people with major depression. ;


Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Prevention


Related Conditions & MeSH terms


NCT number NCT01235533
Study type Interventional
Source Taipei City Psychiatric Center, Taiwan
Contact
Status Completed
Phase N/A
Start date May 2007
Completion date September 2010

See also
  Status Clinical Trial Phase
Completed NCT03735576 - Cognitive Behavioural Therapy for the Treatment of Late Life Depression N/A
Recruiting NCT05007028 - Nitrous Oxide for Late-Life Depression - PROTO-BRAIN N/A
Completed NCT00178087 - Determining Changes in Brain Structure Associated With Symptoms of Late-life Depression N/A
Terminated NCT03564041 - SSM vs HEP in Late-Life Depression N/A