Obese Clinical Trial
Official title:
Comparative Study Between the Effect of Volume-Controlled Ventilation and Pressure-Controlled Ventilation Volume Guaranteed in Obese Patients in Laparoscopic Assisted Surgery
The aim of this study is to compare the efficacy of the pressure controlled ventilation volume-guaranteed (PCV-VG) versus volume-controlled ventilation (VCV) modes as regards lung compliance and oxygenation index in obese patients undergoing laparoscopic assisted surgery especially in Trendelenburg position.
Obesity, defined as a Body Mass Index (BMI) >30 kg.m-2", is characterized by increased airway resistance, labored breathing and decreased respiratory system compliance. An increased rate of obese patients undergoing laparoscopic assisted surgery (LAS) is a health care concern due to anesthesia and ventilation difficulties in the obese population. Therefore, understanding the physiology and pathophysiology of lung function is an important issue during long-lasting LAS. Carbon dioxide pneumoperitoneum with steep Trendelenburg positioning leads to a cranial displacement of the diaphragm and an increased volume of atelectasis, with a consequent decrease of total lung volume, lung compliance, and functional residual capacity. Thus, alleviation of increased airway pressure, improvement in oxygenation and CO2 elimination are the main goals during anesthetic management in laparoscopic assisted surgery. In pressure controlled ventilation volume-guaranteed (PCV-VG) mode, the ventilator regulates the Peak Inspiratory Pressure (PIP) to achieve the optimal TV. To achieve the target volume, ventilator parameters are regularly changed without adjusting airway pressures. Hence, PCV-VG has the advantages of both Volume-Controlled Ventilation (VCV) and pressure controlled ventilation (PCV) to preserve the target minute ventilation while maintaining a low incidence of barotraumas. PCV-VG is a type-controlled ventilation mode with a dual character as it has the criteria of both PCV and VCV. This recent ventilation mode which is one of the pressure regulated volume controlled (PRVC) that include Auto Flow ventilation, offers the ability to reduce the inspiratory pressure and as a result the incidence of barotrauma ;
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT04105075 -
COPD in Obese Patients
|
||
Completed |
NCT04099654 -
The Effect of Core Stabilization Exercise Program in Obese Subjects Awaiting Bariatric Surgery
|
N/A | |
Recruiting |
NCT05857150 -
Exercise Response in Humans With Obesity
|
||
Completed |
NCT03532672 -
Early Effect of Fasting on Metabolic, Inflammatory, and Behavioral Responses in Females With and Without Obesity
|
N/A | |
Completed |
NCT02086448 -
Sleep Disordered Breathing, Obesity and Pregnancy Study (SOAP)
|
N/A | |
Completed |
NCT02618486 -
The Effects of Obesity on Non Surgical Periodontal Therapy
|
N/A | |
Completed |
NCT01724515 -
PGC-1 and Mitochondrial Dysfunction in Diabetes
|
N/A | |
Completed |
NCT01724502 -
Mitochondrial Dysfunction in Diabetes
|
N/A | |
Active, not recruiting |
NCT01634204 -
Efficacy of a Web-based Weight Loss Program
|
Phase 2 | |
Completed |
NCT01479933 -
Glucose Metabolism Effects of Vitamin D Supplementation in Prediabetes
|
N/A | |
Completed |
NCT01421589 -
Growth Hormone Treatment on Phosphocreatine Recovery in Obesity
|
N/A | |
Completed |
NCT03528304 -
Native Women's Wellness: Contingency Management for Tobacco Cessation and Weight Loss
|
N/A | |
Completed |
NCT01467817 -
Obesity/Overweight in Persons With Early and Chronic Spinal Cord Injury (SCI)
|
N/A | |
Completed |
NCT01726647 -
Metabolism Associated With Abdominal Fat Mass Distribution
|
N/A | |
Active, not recruiting |
NCT02125149 -
The Expecting Study
|
N/A | |
Completed |
NCT05737927 -
Pharmacodynamics and Pharmacokinetics of Different Glucose Bead Formulations in Obese Healthy Subjects
|
Phase 1 | |
Completed |
NCT05433506 -
Safety and Pharmacokinetics of HU6
|
Phase 1 | |
Completed |
NCT02871882 -
Ox Bile- Conjugated Bile Acids Sodium in Type II Diabetes Mellitus
|
Phase 2 | |
Completed |
NCT03298464 -
Study of NGM313 in Obese Participants
|
Phase 1 | |
Completed |
NCT05061173 -
Comparison of Aerobic, Resistance, and Combined Training in Overweight/Obese Hypertensive Adults
|
N/A |