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Knee Pain Swelling clinical trials

View clinical trials related to Knee Pain Swelling.

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NCT ID: NCT06466330 Not yet recruiting - Knee Pain Chronic Clinical Trials

Efficacy of Microparticle Geniculate Artery Embolization in Total Knee Prosthesis Patients With Pain Resistant to Medical Treatment. A Prospective Randomized Controlled Trial

EPROGE
Start date: September 15, 2024
Phase: N/A
Study type: Interventional

The goal of this clinical investigation is to evaluate the effectiveness on pain of arterial occlusion (embolization) of neovessels by microparticle in a double-blind sham controlled randomised trial in patients with persistent pain on a total knee prosthesis (TKP), inserted for gonarthrosis, despite well-conducted medical treatment. The study patient population will consist of up to 112 subjects with knee pain for at least 3 months that is resistant to conservative treatment measures. Subjects will be treated with knee embolisation or saline in the sham arm. The efficacy of embolization will be judged on the basis of the following criteria: improvement in pain, mobility, use of pain medication, adverse effects of embolization and duration of improvement. After verification of eligibility criteria, patients with painful total knee prosthesis will be randomized to either the embolization group or the control group. Embolization will be performed using microparticles (Embozene® Microspheres 100 microns from Varian), for the treatment group. For the "sham " group, only diagnostic arteriography will be performed without injection of microparticles. Subjects will be followed up at 1, 3, 6 and 12 months.

NCT ID: NCT06447142 Recruiting - Meniscus Tear Clinical Trials

The Open Kinetic Chain and Closed Kinetic Chain Strengthening Exercises in Degenerative Meniscus Tears

Start date: June 10, 2024
Phase: N/A
Study type: Interventional

This randomized-controlled trial aims to compare the effect of open kinetic chain and closed kinetic chain strengthening exercises on pain, function, and health-related quality of life in degenerative meniscus tears.

NCT ID: NCT06447129 Recruiting - Meniscus Tear Clinical Trials

Effect of NMES as an Add-On to Exercise Program in Degenerative Meniscus Tears

Start date: June 10, 2024
Phase: N/A
Study type: Interventional

This randomized-controlled trial aims to investigate the effect of NMES as an add-on to an exercise program in patients with degenerative meniscus tears.

NCT ID: NCT06330454 Recruiting - Knee Pain Swelling Clinical Trials

Painful Total Knee Replacement (TKA) and I-one Therapy

Start date: October 22, 2020
Phase:
Study type: Observational

Arthroplasty operations are very frequent and their number is constantly increasing. The success of prosthetic surgery is linked to surgical factors (prosthesis type, prosthesis design, prosthesis material, surgical hand) and 'biological' factors (inflammation, pain, oedema, impingement). It is well known that important functional limitations may result mainly from an overreaction involving the peri-articular tissues. This is particularly true after total knee arthroplasty (TKA) surgery, during which a large part of the bone tissue and part of the peri-articular tissues (joint capsule, ligaments, synovium) are dislodged or removed. In the days following arthroplasty operations, the presence of a strong local inflammatory component is associated with pain and functional limitation, which usually resolves within a few months; however, it can sometimes take longer, and sometimes result in a chronic, albeit modest, inflammatory condition that lasts for years. There is still a percentage of 11-25% of patients who remain not completely satisfied with the result achieved with prosthetic surgery . Baker et al. state that 19.8% of patients experience pain one year after arthroplasty . Beswick et al. report that many patients (10-34%) continue to experience significant pain and functional limitation after arthroplasty even years later.

NCT ID: NCT05975879 Completed - Osteoarthritis Clinical Trials

A Study of the Feasibility of Using the Dietary Supplement "ARTNEO" in Patients With Osteoathritis

Start date: May 31, 2022
Phase: N/A
Study type: Interventional

The goal of this clinical study is to evaluate the effectiveness of the properties that support the functional state of the joints and the safety of the dietary supplement for food ARTNEO®, oral capsules, in patients with stage II-III primary osteoarthritis of the knee joint. The main questions it aims to answer are: 1. To evaluate the effectiveness of the joint functional state-supporting properties of dietary supplement ARTNEO®, capsules for oral administration, in patients with stage II-III primary osteoarthritis of the knee joint; 2. To evaluate the safety of dietary supplement ARTNEO®, capsules for oral administration, in patients with stage II-III primary osteoarthritis of the knee joint. Participants will be randomly distributed equally among two groups: - Group 1 "ARTNEO" (106 people): patients take the study dietary supplement ARTNEO®, 1 capsule 1 time per day for 6 months; - Group 2 "Placebo" (106 people): patients take placebo 1 capsule 1 time per day for 6 months.

NCT ID: NCT05886608 Completed - Knee Osteoarthritis Clinical Trials

Evaluation of the Effect of the AI500™ SINGLE-DOSE GEL Medical Device in Patients With Reduced Knee Function

Start date: August 30, 2022
Phase: N/A
Study type: Interventional

Evaluation of the effect of the AI500™ SINGLE-DOSE GEL medical device in patients with reduced knee function

NCT ID: NCT05347602 Completed - Clinical trials for Rheumatoid Arthritis

Gold Factor on Knee Joint Health and Function

Start date: August 3, 2020
Phase: N/A
Study type: Interventional

The purpose of this clinical study was to determine whether gold nanoparticles (AuNP) supplement holds clinical value in improving joint health, function, and quality of life for arthritis patients.

NCT ID: NCT05266365 Enrolling by invitation - Meniscus Tear Clinical Trials

The Video-Based Exercise Programs in Degenerative Meniscus Tears

Start date: April 1, 2022
Phase: N/A
Study type: Interventional

This randomized-controlled trial aims to investigate the efficacy of video-based exercise programs with face-to-face or remote supervision in patients with degenerative meniscus tears.

NCT ID: NCT05261360 Recruiting - Knee Injuries Clinical Trials

Clinical Efficacy of Exosome in Degenerative Meniscal Injury

KNEEXO
Start date: March 2022
Phase: Phase 2
Study type: Interventional

Comparison of intra-articular administration of synovial fluid-derived mesenchymal stem cells-derived exosomes with synovial fluid-derived mesenchymal stem cells on the same patient.

NCT ID: NCT04580069 Completed - Knee Pain Swelling Clinical Trials

Role of Two Rehabilitative Treatments and Diet in the Modulation of Inflammation in Patients With Knee Prosthesis.

Start date: September 30, 2019
Phase: N/A
Study type: Interventional

The investigators studied the influence of two aproved rehabilitative treatments, connective tissue techniques and lymphatic drainage, on acute inflammation markers. Furthermore, the role of mediterranean diet on the same values was investigated in the first postoperative period