Adductor Canal Versus Femoral Nerve Block for Analgesia Post Total Knee Arthroscopy

Knee Osteoarthritis Clinical Trial

Official title:

A Randomised Controlled Trial Comparing Single Shot Adductor Canal Block With Femoral Nerve Block for Analgesia Post Total Knee Arthroplasty

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT02033603
• Other study ID #: 2013/ 921/ D
• Status: Recruiting
• Phase: N/A
• First received: January 9, 2014
• Last updated: December 31, 2014
• Start date: January 2014
• Est. completion date: December 2014

Study information

• Verified date: January 2014
• Source: Changi General Hospital
• Contact: CTRU CGH
• Phone: 67888833
• Is FDA regulated: No
• Health authority: Singapore: Institutional Review Board
• Study type: Interventional

Clinical Trial Summary

Total knee arthroplasty or replacement (TKA) is a surgery performed for osteoarthritis of the knee which is increasingly performed as the population ages. It is a painful surgery and one of the methods to reduce post-operative pain is performing a regional anaesthesia technique. The current practice is to perform a femoral nerve block (FNB) which blocks the nerves supplying the knee joint and the thigh muscles (quadriceps). This provides effective analgesia. However, it also results in weakness of the quadriceps and may result in falls post-operatively.

Adductor canal block (ACB) is a new, alternative regional anaesthesia technique which is hypothesised to provide as effective analgesia, with less quadriceps weakness compared to FNB, hence potentially reducing the risk of falls post-operatively.

Investigators aim to study if the analgesia provided by ACB is as good as FNB while preserving quadriceps strength.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 30
• Est. completion date: December 2014
• Est. primary completion date: September 2014
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 45 Years to 85 Years

Eligibility

Inclusion Criteria:

• ages 45-85

• American Society of Anaesthesiologists physical status 1-3

• BMI 18-35 kg/m2

Exclusion Criteria:

• inability to give consent, communicate, cooperate

• Patients with regular consumption of strong opioids (morphine, oxycodone) or steroids

• Patients with allergy to local anaesthetics or any drugs included in the study

• Patients with lower limb surgery in the preceding year

• Patients with pre-existing neurological deficits

• Patients who are unsuitable for general anaesthetics (eg difficult airway)

Study Design

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Outcomes Assessor), Primary Purpose: Treatment

Related Conditions & MeSH terms

• Knee Osteoarthritis
• Osteoarthritis, Knee

Intervention

Drug:
• Ropivacaine
30mls of 0.5% ropivacaine

Locations

Country	Name	City	State
Singapore	Changi General Hospital	Singapore

Sponsors (1)

Lead Sponsor	Collaborator
Changi General Hospital

Country where clinical trial is conducted

Singapore, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Morphine consumption		first 24 hours	No
Secondary	Pain scores		1, 6, 12, 24, 48	No
Secondary	Morphine consumption		48 hours	No
Secondary	Side effects of opioids- sedation, nausea and vomiting		48 hours	Yes
Secondary	Quadriceps strength, ability to mobilise		24, 48 hours	No