Knee Osteoarthritis Clinical Trial
Official title:
A Study of Strengthening Exercise on Quadriceps Force During Walking
This is a longitudinal, randomized, controlled interventional multi centric study on the
effects of lower leg strengthening exercise on quadriceps force during walking in people
with knee osteoarthritis. At each study centre twenty subjects will be included, for a total
of 40 participants. Subjects will be randomized equally (1:1) into 1 active arm and 1
control arm.
The objective of the study is to evaluate the effect of twelve weeks of quadriceps
strengthening on the mechanical output of the quadriceps during locomotion. A secondary
purpose is to explore the relationship between quadriceps strengthening and compressive knee
loadings. The hypothesis is that quadriceps strength training will not change quadriceps
force, power, and work in locomotion in people with knee osteoarthritis.
Primary outcome is quadriceps force during walking, secondary outputs are quadriceps power
and work and knee compressive loads during walking. Explorative measures are isometric and
concentric isokinetic leg muscle strength, radiographic score of the knee (Kellgren and
Lawrence), a one-leg rise from chair test (maximum number of reps) and a lateral step-up
test (maximum number of reps).
n/a
Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Basic Science
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