Mitigation of Arthrofibrosis After Total Knee Arthroplasty Using Losartan

Status Recruiting

Clinical Trial Summary

The purpose of this study is to evaluate the efficacy of Losartan use post-operatively for reducing or preventing the development of arthrofibrosis and the associated adverse impacts on clinical outcomes.

Clinical Trial Description

This is a double-blind, randomized, placebo-controlled clinical trial proposed to evaluate the efficacy and safety of Losartan for reducing or preventing arthrofibrosis and improving patient-reported outcomes after total knee arthroplasty (TKA). Fibrosis will be evaluated over time after TKA using measures of knee range of motion and capsular thickening. 120 patients scheduled to undergo total knee arthroplasty will be recruited from the clinical practice of the Principal Clinical Investigator or his designee at The Steadman Clinic (TSC) and randomized into one of two arms (1:1). ;

Study Design

Related Conditions & MeSH terms

Knee Arthroplasty, Total

Clinical Trial Details

NCT number	NCT06108063
Study type	Interventional
Source	Steadman Philippon Research Institute
Contact	Suzanne L Page, JD
Phone	970-401-8770
Email	spage@sprivail.org
Status	Recruiting
Phase	Phase 1/Phase 2
Start date	March 6, 2024
Completion date	June 30, 2027

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT04226339` - Evaluation of Walking Analysis After a Total Knee Arthroplasty With Kinematic Alignment Versus Mechanical Alignment	N/A
Completed	`NCT03276143` - FactOr XIa inhibiTion for the pRevention of venOus Thromboembolism in Patients Undergoing Total Knee Arthroplasty	Phase 2
Completed	`NCT03308071` - Hypnosis for Symptom Management in Elective Orthopedic Surgery	N/A
Recruiting	`NCT05100706` - Continuous Adductor Canal Block in Outpatient Total Knee Arthroplasty	N/A
Completed	`NCT04090125` - Improving Physical Activity and Gait Symmetry After Total Knee Arthroplasty	N/A
Recruiting	`NCT04564729` - Shared Decision Aid for Post-Total Knee Arthroplasty Opioid Prescribing	N/A
Recruiting	`NCT03695640` - Effect of Magnesium Sulphate on Analgesia Following Knee Arthroplasty	Phase 4
Recruiting	`NCT05877261` - Cementless Triathlon 5YR Follow-Up
Recruiting	`NCT05516381` - Evaluation of Navigation-Assisted TKA Using Mechanical vs. Restricted Kinematic Alignment	N/A
Completed	`NCT04450485` - Surgical Approach in Fast Track Knee Arthroplasty	N/A
Recruiting	`NCT06389435` - RObotic-assisted Versus Conventional Knee Endoprosthetic Techniques	N/A
Completed	`NCT03898544` - Gait Kinematics After Primary Total Knee Arthroplasty (TKA) Versus Revision TKA
Completed	`NCT03492320` - Progression of Health Related Quality of Life of Patients Waiting for Total Knee Arthroplasty
Active, not recruiting	`NCT02445443` - LEGION Hinge Safety and Efficacy Study
Terminated	`NCT02830087` - Tourniquet Pressure in Primary Total Knee Arthroplasty	N/A
Completed	`NCT02186587` - iTotal Pilot Study of ConforMIS Custom Total Knee Implant	N/A
Completed	`NCT00711711` - Manual Lymphatic Drainage Following Total Knee Arthroplasty Surgery	N/A
Active, not recruiting	`NCT05788757` - Optetrak Knee System Post Market Clinical Follow-Up
Completed	`NCT03703206` - The Analgesic Efficacy of Protocol for Primary Total Knee Arthroplasty (TKA)	Phase 3
Completed	`NCT02947321` - Genicular Radiofrequency Ablation Efficacy in Achieving Total Knee Pain Reduction Trial	N/A