Clinical Trials Logo

Clinical Trial Summary

The purpose of this study is to evaluate the efficacy of Losartan use post-operatively for reducing or preventing the development of arthrofibrosis and the associated adverse impacts on clinical outcomes.


Clinical Trial Description

This is a double-blind, randomized, placebo-controlled clinical trial proposed to evaluate the efficacy and safety of Losartan for reducing or preventing arthrofibrosis and improving patient-reported outcomes after total knee arthroplasty (TKA). Fibrosis will be evaluated over time after TKA using measures of knee range of motion and capsular thickening. 120 patients scheduled to undergo total knee arthroplasty will be recruited from the clinical practice of the Principal Clinical Investigator or his designee at The Steadman Clinic (TSC) and randomized into one of two arms (1:1). ;


Study Design


Related Conditions & MeSH terms


NCT number NCT06108063
Study type Interventional
Source Steadman Philippon Research Institute
Contact Suzanne L Page, JD
Phone 970-401-8770
Email spage@sprivail.org
Status Recruiting
Phase Phase 1/Phase 2
Start date March 6, 2024
Completion date June 30, 2027

See also
  Status Clinical Trial Phase
Recruiting NCT04226339 - Evaluation of Walking Analysis After a Total Knee Arthroplasty With Kinematic Alignment Versus Mechanical Alignment N/A
Completed NCT03276143 - FactOr XIa inhibiTion for the pRevention of venOus Thromboembolism in Patients Undergoing Total Knee Arthroplasty Phase 2
Completed NCT03308071 - Hypnosis for Symptom Management in Elective Orthopedic Surgery N/A
Recruiting NCT05100706 - Continuous Adductor Canal Block in Outpatient Total Knee Arthroplasty N/A
Completed NCT04090125 - Improving Physical Activity and Gait Symmetry After Total Knee Arthroplasty N/A
Recruiting NCT04564729 - Shared Decision Aid for Post-Total Knee Arthroplasty Opioid Prescribing N/A
Recruiting NCT03695640 - Effect of Magnesium Sulphate on Analgesia Following Knee Arthroplasty Phase 4
Recruiting NCT05877261 - Cementless Triathlon 5YR Follow-Up
Recruiting NCT05516381 - Evaluation of Navigation-Assisted TKA Using Mechanical vs. Restricted Kinematic Alignment N/A
Completed NCT04450485 - Surgical Approach in Fast Track Knee Arthroplasty N/A
Completed NCT03898544 - Gait Kinematics After Primary Total Knee Arthroplasty (TKA) Versus Revision TKA
Completed NCT03492320 - Progression of Health Related Quality of Life of Patients Waiting for Total Knee Arthroplasty
Active, not recruiting NCT02445443 - LEGION Hinge Safety and Efficacy Study
Terminated NCT02830087 - Tourniquet Pressure in Primary Total Knee Arthroplasty N/A
Completed NCT02186587 - iTotal Pilot Study of ConforMIS Custom Total Knee Implant N/A
Completed NCT00711711 - Manual Lymphatic Drainage Following Total Knee Arthroplasty Surgery N/A
Recruiting NCT05788757 - Optetrak Knee System Post Market Clinical Follow-Up
Completed NCT03703206 - The Analgesic Efficacy of Protocol for Primary Total Knee Arthroplasty (TKA) Phase 3
Completed NCT02947321 - Genicular Radiofrequency Ablation Efficacy in Achieving Total Knee Pain Reduction Trial N/A
Recruiting NCT05653102 - A Post-Market Domestic (US) and International Data Collection to Assess the Truliant Knee System