Perioperative Factors and Early Postoperative Kidney Graft Function Recovery

Kidney Transplant; Complications Clinical Trial

Official title:

Analysis of Perioperative Factors Affecting Early Postoperative Kidney Graft Function Recovery in Patients Undergoing Living Kidney Transplant Surgery

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT06280898
• Other study ID #: KC22RISI0395
• Status: Completed
• Start date: May 1, 2020
• Est. completion date: March 14, 2022

Study information

• Verified date: February 2024
• Source: Seoul St. Mary's Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Divided into two groups based on acute kidney injury: non-acute kidney injury group vs. non-acute kidney injury group. Acute kidney injury group, Acute Kidney Injury Network (AKIN), Risk, Injury, Failure, Loss of kidney function, and End-stage kidney disease (RIFLE), or Kidney Disease: Improving Global Outcomes (KDIGO) I would like to divide it according to the definition. After testing the normal distribution of patients, donors, grafts, types of immunosuppressants, surgery/anesthesia factors, and blood test findings between the two groups through the Shapiro-Wilk test, continuous data was tested using the student t-test or Mann-Whitney U test. Sizes are compared using , and categorical data is compared with proportions using the χ2 test or Fisher's exact test. Analysis of factors related to acute kidney injury will be performed through univariate and multivariate logistic regression analysis.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 539
• Est. completion date: March 14, 2022
• Est. primary completion date: March 14, 2022
• Accepts healthy volunteers: No
• Gender: All
• Age group: 19 Years to 80 Years

Eligibility

Inclusion Criteria:

• Adult patients aged 19 years or older who underwent kidney transplant surgery in the operating room

Exclusion Criteria:

• Pediatric patients under 19 years of age
• Patients with multiple organ transplants, including kidney transplants
• Patients undergoing re-kidney transplant surgery
• Patient examination findings missing from electronic medical record

Related Conditions & MeSH terms

• Heart Injuries
• Kidney Transplant; Complications

Intervention

Procedure:
• Remote ischemic conditioning
Remote ischemic condition

Locations

Country	Name	City	State
Korea, Republic of	Seoul St. Mary's hospital	Seoul

Sponsors (1)

Lead Sponsor	Collaborator
Seoul St. Mary's Hospital

Country where clinical trial is conducted

Korea, Republic of, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Troponin I	Troponin I difference in two groups	up to 24 hour postoperatively
Secondary	Troponin T	Troponin T difference in two groups	up to 24 hour postoperatively
Secondary	QTc interval	OTc interval difference in two groups	up to 24 hour postoperatively