A Pilot Study of Oxalate Absorption in Secondary Hyperoxaluria

Status Completed

Clinical Trial Summary

Identify individuals with greater absorption of oxalate based on increase in urinary oxalate excretion in response to a controlled oxalate-rich test meal.

Clinical Trial Description

This was a prospective 4-day study of oxalate absorption in subjects with secondary hyperoxaluria. Subjects visited the research center three times for outpatient visits (Screening, Test Day 3, Day 4). Subjects were instructed to follow a low-oxalate diet, consuming only study-specified food choices that had low or no oxalate and controlled calcium content Days 1 through 4 (Baseline Period through the Day 4 clinic visit) and, on Test Day 3, consumed an oxalate-rich test meal. Subjects performed three 24-hour urine collections during Screening, Baseline Day 2, and Test Day 3. Test Day 3 included the oxalate-rich test meal and the subject collected a 24-hour urine separated into 4 urine collection intervals. (Pre-test meal, post-test meal to 4 hours, 4-6 hours post test meal and remaining time to complete 24 hours). ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03095885
Study type	Interventional
Source	Allena Pharmaceuticals
Contact
Status	Completed
Phase	N/A
Start date	November 2016
Completion date	March 2017

View Details

See also
Status	Clinical Trial	Phase
Enrolling by invitation	`NCT04746378` - PRedictive Accuracy of Initial Stone Burden Evaluation.
Recruiting	`NCT05100017` - Methocarbamol vs Oxybutynin for Management of Pain and Discomfort S/P Ureteroscopy Procedure	N/A
Recruiting	`NCT03692715` - Antibiotic Prophylaxis Before Shock Wave Lithotripsy	Phase 4
Completed	`NCT02547805` - Evaluate the Effect of ALLN-177 in Reducing Urinary Oxalate in Patients With Secondary Hyperoxaluria and Kidney Stones Over 28 Days	Phase 2
Completed	`NCT02289755` - Evaluating ALLN-177 for Reducing Urinary Oxalate Excretion in Calcium Oxalate Kidney Stone Formers With Hyperoxaluria	Phase 2
Completed	`NCT01690039` - Influence of Polymorphisms in the ATP6V1 Gene of the V-ATPase on the Development of Incomplete Distal Renal Tubular Acidosis
Completed	`NCT01650935` - Comparison of DASH With Oxalate Restricted Diet on Urine in Recurrent Stone Formers With Hyperoxaluria	N/A
Completed	`NCT01295879` - Vitamin D Repletion in Stone Formers With Hypercalciuria	Phase 4
Recruiting	`NCT05014178` - Kidney Sodium Functional Imaging
Not yet recruiting	`NCT06199102` - The High Initial Dose of Monitored Vitamin D Supplementation in Preterm Infants.	N/A
Recruiting	`NCT04374188` - Efficacy of Ciprofloxacin Therapy in Avoidance of Sepsis in Patient Undergoing Percutanous Nephrolithotomy	N/A
Recruiting	`NCT04367155` - Efficacy of Tranexamic Acid on Blood Loss During Percutaneous Nephrolithotomy.	N/A
Recruiting	`NCT05701098` - SOUND Pivotal Trial - (Sonomotion stOne comminUtion resoNance ultrasounD)	N/A
Recruiting	`NCT04389853` - Mini-PNCL vs fURS in Management of Nephrolithiasis	N/A
Completed	`NCT03348228` - Effect of Hydroxycitrate on Urine Chemistry	N/A
Completed	`NCT05350423` - Trial Assessing Renal Damage During Ureteroscopy	N/A
Completed	`NCT03454139` - Subcostal TAP Block For Percutaneous Nephrolithotomy	N/A
Recruiting	`NCT02279927` - Prospective Comparison Between Different Laser Settings for Ureteral \ Kidney Stones Treatment During Ureteroscopy	N/A
Completed	`NCT02276924` - Diagnostic Relevance of Laser Confocal Microscopy for the Screening of Upper Urinary Tract Tumors	N/A
Completed	`NCT00159393` - Percutaneous Nephrolithotomy: A Registry and Database