Nephrolithiasis Clinical Trial
Official title:
A Phase 2, Multicenter, Randomized, Placebo-controlled, Double-blind Study to Evaluate the Efficacy and Safety of ALLN-177 Treatment Over 28 Days in Patients With Secondary Hyperoxaluria and Kidney Stones
Evaluate the safety, tolerability, and efficacy of 28 days of treatment with ALLN-177 for reducing urinary oxalate excretion in patients with secondary hyperoxaluria and kidney stones.
This is a multicenter, randomized, double-blind, placebo controlled study to evaluate the
efficacy of ALLN 177 compared with placebo in reducing the urinary excretion of oxalate in
subjects with secondary hyperoxaluria and kidney stones. ALLN-177 is an orally administered
form of oxalate decarboxylase. The goal of therapy with ALLN-177 is to reduce urinary
oxalate excretion by decreasing the absorption of oxalate from the gastrointestinal tract.
Eligible subjects will be randomized to 28 days of treatment with ALLN-177 (7,500 units) or
placebo three times daily with meals. Urinary oxalate excretion will be assessed by 24-hr
urine collections throughout the study.
The study allows for approximately 66 subjects. The number of enrolled subjects may be
increased to a maximum of 100 following an interim analysis.
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